PMID- 22836186
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20220330
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 32
IP  - 2
DP  - 2012
TI  - Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal 
      BDNF and arc levels and impairs memory in young mice.
PG  - 341-55
LID - 10.3233/JAD-2012-120697 [doi]
AB  - The presence of the E4 allele of apolipoprotein E (apoE) is the strongest known 
      genetic risk factor for sporadic Alzheimer's disease (AD). Other risk factors for 
      developing AD have been identified, including lifestyle such as dietary habits. 
      The present study was designed to explore the impact of the interaction between 
      variant human apoE isoforms and a high carbohydrate diet (HCD) on mechanisms 
      behind learning and memory retention. As an investigative model, we compared 
      young apoE3 and apoE4 target replacement mice fed on a HCD for 6 months. Our 
      results indicate that HCD compromises memory processes in apoE4 mice. ApoE4 mice 
      on HCD showed decreased activity-regulated cytoskeletal-associated protein (Arc) 
      and brain derived neurotrophic factor (BDNF) levels, as well as decreased BDNF 
      signaling in the hippocampus. In contrast, apoE3 mice were resistant to the 
      deleterious effects of HCD on both behavior and memory-related proteins. Our 
      results support the hypothesis that already in mid-life, genetic, and 
      environmental risk factors act together on the mechanisms behind cognitive 
      impairment.
FAU - Maioli, Silvia
AU  - Maioli S
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska 
      Institutet-Alzheimer Disease Research Center, NOVUM, Stockholm, Sweden. 
      Silvia.Maioli@ki.se
FAU - Puerta, Elena
AU  - Puerta E
FAU - Merino-Serrais, Paula
AU  - Merino-Serrais P
FAU - Fusari, Laura
AU  - Fusari L
FAU - Gil-Bea, Francisco
AU  - Gil-Bea F
FAU - Rimondini, Roberto
AU  - Rimondini R
FAU - Cedazo-Minguez, Angel
AU  - Cedazo-Minguez A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (activity regulated cytoskeletal-associated protein)
SB  - IM
MH  - Animals
MH  - Apolipoprotein E4/*genetics/metabolism
MH  - Avoidance Learning/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cytoskeletal Proteins/*metabolism
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Hippocampus/*drug effects/metabolism
MH  - Maze Learning/drug effects/physiology
MH  - Memory/*drug effects/physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Tissue Proteins/*metabolism
EDAT- 2012/07/28 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - B5T05494H713RP5R [pii]
AID - 10.3233/JAD-2012-120697 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2012;32(2):341-55. doi: 10.3233/JAD-2012-120697.