PMID- 22836900
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20220318
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 33
IP  - 1
DP  - 2013 Jan
TI  - Peripheral polypoidal choroidal vasculopathy as a cause of peripheral exudative 
      hemorrhagic chorioretinopathy: a report of 10 eyes.
PG  - 48-55
LID - 10.1097/IAE.0b013e31825df12a [doi]
AB  - PURPOSE: Polypoidal choroidal vasculopathy (PCV) is characterized by polyp-like 
      sub-retinal pigment epithelium vascular abnormalities predominantly found in the 
      macula and peripapillary region. Less commonly, PCV can be found peripherally and 
      be a cause of peripheral exudative hemorrhagic chorioretinopathy (PEHCR). We 
      sought to further describe the clinical spectrum of this ill-defined subgroup of 
      PEHCR. METHODS: A retrospective observational case series, of 10 eyes of 8 
      patients diagnosed with PEHCR caused by peripheral PCV, was conducted. In all 
      cases, the presence of PCV was confirmed with indocyanine green angiography 
      and/or fluorescein angiography and optical coherence tomography. The clinical 
      presentation, natural history, and clinical outcomes with or without intervention 
      were studied. RESULTS: Patients with PEHCR caused by peripheral PCV were most 
      commonly men, white, asymptomatic, and had a concomitant diagnosis of age-related 
      macular degeneration. The mean age was 70 years (range, 59-82 years) with a mean 
      follow-up of 32.5 months (range, 4-91 months). Four patients had unilateral 
      involvement with minimal subretinal hemorrhage that resolved spontaneously, one 
      patient had unilateral involvement outside the macula that responded to 
      anti-vascular endothelial growth factor therapy, one patient had unilateral 
      involvement with subretinal hemorrhage threatening the macula that responded to 
      anti-vascular endothelial growth factor therapy, and two patients had extensive 
      bilateral subretinal hemorrhage requiring surgical intervention. Both patients 
      with multiple lesions in one eye had bilateral lesions (two of eight patients). 
      Lesions were most commonly located in the temporal periphery (8 of 10 eyes). 
      CONCLUSION: A new subclassification is proposed that includes both eyes with 
      polyps and those without polyps within the spectrum of disease described 
      previously as PEHCR. Within the spectrum of disease described previously as PEHCR 
      exists a subgroup of lesions caused by peripheral PCV, which has not been well 
      defined before this report. The largest case series to date of eyes with PEHCR 
      due to peripheral PCV, a unique form of type 1 neovascularization, is further 
      classified and described. These eyes have a spectrum of disease, including small, 
      medium-sized, and large lesions. Although most eyes with PEHCR from peripheral 
      PCV experience a benign course with spontaneous resolution, a subset of eyes may 
      experience macula-threatening hemorrhage, requiring treatment with laser-based 
      therapies, anti-vascular endothelial growth factor injections, or surgical 
      intervention.
FAU - Goldman, Darin R
AU  - Goldman DR
AD  - Department of Ophthalmology, Jules Stein Eye Institute, UCLA Geffen School of 
      Medicine, Los Angeles, California 90095, USA.
FAU - Freund, K Bailey
AU  - Freund KB
FAU - McCannel, Colin A
AU  - McCannel CA
FAU - Sarraf, David
AU  - Sarraf D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid Diseases/*complications/diagnosis
MH  - Choroid Hemorrhage/diagnosis/*etiology
MH  - Coloring Agents
MH  - Exudates and Transudates
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Humans
MH  - Indocyanine Green
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/*complications/diagnosis
MH  - Polyps/*complications/diagnosis
MH  - Retinal Hemorrhage/diagnosis/*etiology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
EDAT- 2012/07/28 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - 10.1097/IAE.0b013e31825df12a [doi]
PST - ppublish
SO  - Retina. 2013 Jan;33(1):48-55. doi: 10.1097/IAE.0b013e31825df12a.