PMID- 22837190
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20220316
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 97
IP  - 10
DP  - 2012 Oct
TI  - Effects of exercise on sRAGE levels and cardiometabolic risk factors in patients 
      with type 2 diabetes: a randomized controlled trial.
PG  - 3751-8
LID - 10.1210/jc.2012-1951 [doi]
AB  - CONTEXT: Low levels of soluble receptor for advanced glycation end-products 
      (sRAGE) have been linked to systemic inflammation and vascular complications in 
      patients with type 2 diabetes mellitus (T2DM). OBJECTIVE: We examined the effects 
      of exercise on sRAGE and its association with diverse cardiometabolic risk 
      factors and indicators of atherosclerosis in patients with T2DM. DESIGN, SETTING, 
      AND PARTICIPANTS: Seventy-five patients with T2DM were randomized into a control 
      group and an aerobic exercise group (60 min at moderate intensity, five times/wk 
      for 12 wk). MAIN OUTCOME MEASURES: We evaluated sRAGE, energy expenditure, 
      dietary energy intake, cardiorespiratory fitness, inflammatory markers, visceral 
      fat area, pulse-wave velocity, and flow-mediated dilatation. RESULTS: Baseline 
      sRAGE concentrations were independently associated with age, glycated hemoglobin, 
      glucose, triglyceride, and high-density lipoprotein cholesterol levels 
      (R2=0.244). After 12 wk of exercise training, the exercise group showed 
      significantly decreased body weight, waist circumference, blood pressure, 
      glycated hemoglobin, apolipoprotein B, and free fatty acid levels. Concurrently, 
      cardiorespiratory fitness assessed by oxygen uptake at anaerobic threshold was 
      improved, and body fat percentage and visceral fat area were significantly 
      decreased in the exercise group, although pulse-wave velocity and flow-mediated 
      dilatation were not changed. Furthermore, sRAGE levels were increased and 
      high-sensitivity C-reactive protein levels were decreased in the exercise group 
      but not in the control group. Percent change of sRAGE level was negatively 
      correlated with that of high-sensitivity C-reactive protein during the study 
      period (r=-0.27; P=0.019). CONCLUSIONS: Aerobic exercise increases sRAGE levels 
      along with improvement of various cardiometabolic risk factors in patients with 
      T2DM.
FAU - Choi, Kyung Mook
AU  - Choi KM
AD  - Department of Internal Medicine, College of Medicine, Korea University, and 
      Department of Internal Medicine, Diabetes Center, Eulji Hospital, Seoul, Korea.
FAU - Han, Kyung Ah
AU  - Han KA
FAU - Ahn, Hee Jung
AU  - Ahn HJ
FAU - Hwang, Soon Young
AU  - Hwang SY
FAU - Hong, Ho Cheol
AU  - Hong HC
FAU - Choi, Hae Yoon
AU  - Choi HY
FAU - Yang, Sae Jeong
AU  - Yang SJ
FAU - Yoo, Hye Jin
AU  - Yoo HJ
FAU - Baik, Sei Hyun
AU  - Baik SH
FAU - Choi, Dong Seop
AU  - Choi DS
FAU - Min, Kyung Wan
AU  - Min KW
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120726
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Atherosclerosis/*epidemiology/metabolism/therapy
MH  - Body Composition/physiology
MH  - Diabetes Mellitus, Type 2/*epidemiology/metabolism/*therapy
MH  - Energy Metabolism/physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Inflammation/epidemiology/metabolism/therapy
MH  - Middle Aged
MH  - Prevalence
MH  - Program Evaluation
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*blood
MH  - Risk Factors
MH  - Risk Reduction Behavior
EDAT- 2012/07/28 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - jc.2012-1951 [pii]
AID - 10.1210/jc.2012-1951 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2012 Oct;97(10):3751-8. doi: 10.1210/jc.2012-1951. Epub 
      2012 Jul 26.