PMID- 22837877
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220309
IS  - 2093-0887 (Electronic)
IS  - 2093-0879 (Print)
IS  - 2093-0879 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Jul
TI  - Role of Acid and weakly acidic reflux in gastroesophageal reflux disease off 
      proton pump inhibitor therapy.
PG  - 291-7
LID - 10.5056/jnm.2012.18.3.291 [doi]
AB  - BACKGROUND/AIMS: Available data about reflux patterns and symptom determinants in 
      the gastroesophageal reflux disease (GERD) subtypes off proton pump inhibitor 
      (PPI) therapy are lacking. We aimed to evaluate reflux patterns and determinants 
      of symptom perception in patients with GERD off PPI therapy by impedance-pH 
      monitoring. METHODS: We retrospectively reviewed the impedance-pH data in 
      patients diagnosed as GERD based on results of impedance-pH monitoring, endoscopy 
      and/or typical symptoms. The characteristics of acid and weakly acidic reflux 
      were evaluated. Symptomatic and asymptomatic reflux were compared according to 
      GERD subtypes and individual symptoms. RESULTS: Forty-two patients (22 males, 
      mean age 46 years) were diagnosed as GERD (17 erosive reflux disease, 9 pH(+) 
      non-erosive reflux disease [NERD], 9 hypersensitive esophagus and 7 symptomatic 
      NERD). A total of 1,725 reflux episodes were detected (855 acid [50%], 857 weakly 
      acidic [50%] and 13 weakly alkaline reflux [< 1%]). Acid reflux was more 
      frequently symptomatic and bolus clearance was longer compared with weakly acidic 
      reflux. In terms of globus, weakly acidic reflux was more symptomatic. 
      Symptomatic reflux was more frequently acid and mixed reflux; these associations 
      were more pronounced in erosive reflux disease and symptomatic NERD. The 
      perception of regurgitation was related to acid reflux, while that of globus was 
      more related to weakly acidic reflux. CONCLUSIONS: In patients not taking PPI, 
      acid reflux was more frequently symptomatic and had longer bolus clearance. 
      Symptomatic reflux was more frequently acid and mixed type; however, weakly 
      acidic reflux was associated more with globus. These data suggest a role for 
      impedance-pH data in the evaluation of globus.
FAU - Sung, Hea Jung
AU  - Sung HJ
AD  - Division of Gastroenterology, Department of Internal Medicine, The Catholic 
      University of Korea, College of Medicine, Seoul, Korea.
FAU - Cho, Yu Kyung
AU  - Cho YK
FAU - Moon, Sung Jin
AU  - Moon SJ
FAU - Kim, Jin Su
AU  - Kim JS
FAU - Lim, Chul Hyun
AU  - Lim CH
FAU - Park, Jae Myung
AU  - Park JM
FAU - Lee, In Seok
AU  - Lee IS
FAU - Kim, Sang Woo
AU  - Kim SW
FAU - Choi, Myung-Gye
AU  - Choi MG
LA  - eng
PT  - Journal Article
DEP - 20120710
PL  - Korea (South)
TA  - J Neurogastroenterol Motil
JT  - Journal of neurogastroenterology and motility
JID - 101530189
PMC - PMC3400817
OTO - NOTNLM
OT  - Electric impedance
OT  - Esophageal pH Monitoring
OT  - Gastroesophageal reflux
COIS- Conflicts of interest: None.
EDAT- 2012/07/28 06:00
MHDA- 2012/07/28 06:01
PMCR- 2012/07/01
CRDT- 2012/07/28 06:00
PHST- 2012/02/23 00:00 [received]
PHST- 2012/04/28 00:00 [revised]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/07/28 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 10.5056/jnm.2012.18.3.291 [doi]
PST - ppublish
SO  - J Neurogastroenterol Motil. 2012 Jul;18(3):291-7. doi: 10.5056/jnm.2012.18.3.291. 
      Epub 2012 Jul 10.