PMID- 22839707
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20170310
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 52
IP  - 7
DP  - 2012
TI  - [Clinical and prognostic significance of multifocal atherosclerosis in patients 
      with acute coronary syndromes without ST-segment elevation].
PG  - 4-8
AB  - Aim of the study was to determine incidence of multifocal atherosclerosis (MFA), 
      to assess its clinical and prognostic significance in the hospital phase in 
      patients with non-ST elevation acute coronary syndrome (NSTEACS). We studied data 
      from 225 patients with duration of NSTEACS 48 hours or less, who along with usual 
      examination were subjected to coronary angiography and color duplex scanning of 
      extracranial arteries and arteries of lower extremities. As lesions we considered 
      any stenosis irrespective of intima media thickness. MFA was detected in 43.6% of 
      cases. Patients with MFA were older, they more often had history of myocardial 
      infarction, had lower creatinine clearance, and left ventricular ejection 
      fraction. Presence of artery stenoses in 3 vascular regions was associated with 
      multivessel coronary artery disease. Inhospital "endpoints" (myocardial 
      infarction, stroke, death) occurred more frequently in patients with MFA. 
      Patients with lesions in 2 and 3 vascular beds were characterized by maximal 
      Grace score, while those without coronary and peripheral artery involvement- by 
      minimal Grace score. The presence of MFA in patients with NSTEACS was associated 
      with unfavourable course of the disease. Thus ptatients with MFA were 
      characterized by high average rating on Grace scale; involvement of three 
      vascular beds was associated with high mortality.
FAU - Berns, S A
AU  - Berns SA
FAU - Zykova, D S
AU  - Zykova DS
FAU - Shmidt, E A
AU  - Shmidt EA
FAU - Iukhno, E S
AU  - Iukhno ES
FAU - Chuvichkina, O V
AU  - Chuvichkina OV
FAU - Zykov, M V
AU  - Zykov MV
FAU - Barbarash, O L
AU  - Barbarash OL
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
SB  - IM
MH  - Acute Coronary Syndrome/epidemiology/*etiology/therapy
MH  - *Atherosclerosis/complications/epidemiology/pathology/physiopathology
MH  - Carotid Arteries/*pathology
MH  - Constriction, Pathologic/*diagnosis
MH  - Coronary Angiography/methods
MH  - Electrocardiography/methods
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Incidence
MH  - Lower Extremity/blood supply
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Siberia/epidemiology
MH  - Stroke Volume
MH  - Survival Analysis
MH  - Ultrasonography, Doppler, Color/methods
EDAT- 2012/07/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Kardiologiia. 2012;52(7):4-8.