PMID- 22841239
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20120730
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 6
DP  - 2012 Jul-Aug
TI  - Human leukocyte antigen and major histocompatibility complex class I-related 
      chain A antibodies after kidney transplantation in Turkish renal transplant 
      recipients.
PG  - 1660-6
LID - 10.1016/j.transproceed.2012.04.018 [doi]
AB  - BACKGROUND: This study was designed to determine whether human leukocyte antigen 
      (HLA) and major histocompatibility complex class I chain-related A (MICA) 
      antibody (Ab) production during the first 6 months posttransplantation correlated 
      with long-term graft survival and rejection rate. The study group included 147 
      first transplantations from either living related (LRDs) or deceased donors (DDs) 
      who were divided into two subgroups: rejection (RG, n = 28) and nonrejection 
      (NRG, n = 119). Serum samples (n = 441) collected from each patient on 
      posttransplant days 30, 90, and 180 were tested for HLA and MICA Ab using the 
      Luminex technique. RESULTS: Among 82 Ab-positive patients (55.8%), 40 had both 
      HLA and MICA, 33 only HLA, and 9 only MICA Ab in the posttransplant period. The 
      rates of HLA class I, class II, or both Ab positivities were greater in the RG 
      than the NRG (P = .011, .037, and .0275, respectively). At 180 days 
      posttransplant, 64.3% of patients in the RG had Ab and 41.2% in the NRG (P = 
      .0349). The data for the LRD (n = 116) group were similar to those for the entire 
      group; whereas there was no significant difference in Ab positivity between RG 
      and NRG patients who received organs from DDs. There was no significant 
      difference with respect to HLA class II and/or MICA Ab positivity between RG and 
      NRG among patients who lacked HLA class I Ab. DISCUSSION: We confirmed that HLA 
      and MICA Ab may be harmful posttransplant, promoting rejection processes and 
      representing an important cause of graft failure. HLA class II and MICA Ab 
      positivities were only important predictors of graft failure when present 
      together with HLA class I positivity. Patients who developed HLA alone or both 
      HLA and MICA Ab rejected their grafts more frequently than Ab-negative 
      recipients.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Seyhun, Y
AU  - Seyhun Y
AD  - Department of Medical Biology, Istanbul University, Istanbul, Turkey. 
      dryseyhun@yahoo.com
FAU - Ozdilli, K
AU  - Ozdilli K
FAU - Oguz, F
AU  - Oguz F
FAU - Karahan, G
AU  - Karahan G
FAU - Onal, E
AU  - Onal E
FAU - Turkmen, A
AU  - Turkmen A
FAU - Eldegez, U
AU  - Eldegez U
FAU - Nane, I
AU  - Nane I
FAU - Caliskan, Y
AU  - Caliskan Y
FAU - Bakkaloglu, H
AU  - Bakkaloglu H
FAU - Carin, M
AU  - Carin M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Isoantibodies)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Graft Rejection/immunology
MH  - Graft Survival
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/*blood
MH  - Kidney Transplantation/*immunology
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - Turkey
MH  - Young Adult
EDAT- 2012/07/31 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S0041-1345(12)00414-9 [pii]
AID - 10.1016/j.transproceed.2012.04.018 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Jul-Aug;44(6):1660-6. doi: 
      10.1016/j.transproceed.2012.04.018.