PMID- 22841897
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220310
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 132
IP  - 3-5
DP  - 2012 Nov
TI  - 1alpha,25-Dihydroxyvitamin D(3) inhibits vascular cellular adhesion molecule-1 
      expression and interleukin-8 production in human coronary arterial endothelial 
      cells.
PG  - 290-4
LID - S0960-0760(12)00139-2 [pii]
LID - 10.1016/j.jsbmb.2012.07.003 [doi]
AB  - Kawasaki disease is an acute febrile vasculitis of childhood that is associated 
      with elevated production of inflammatory cytokines, causing damage to the 
      coronary arteries. The production of proinflammatory cytokines and expression of 
      adhesion molecules in human coronary arterial endothelial cells (HCAECs) is 
      regulated by nuclear transcription factor-kappaB (NF-kappaB) activation. We have 
      previously reported that the active form of vitamin D, 1alpha,25-dihydroxyvitamin 
      D(3) (1alpha,25-(OH)(2)D(3)), inhibits tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB 
      activation. In this study, we examined the anti-inflammatory effects of 
      1alpha,25-(OH)(2)D(3) on TNF-alpha-induced adhesion molecule expression (vascular 
      cellular adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 
      (ICAM-1)) and cytokine production (interleukin-6 (IL-6) and IL-8) in HCAECs. 
      Pretreatment with 1alpha,25-(OH)(2)D(3) significantly inhibited TNF-alpha-induced VCAM-1 
      expression and IL-8 production in HCAECs. Our results suggest that adjunctive 
      1alpha,25-(OH)(2)D(3) therapy may modulate the inflammatory response during Kawasaki 
      disease vasculitis.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kudo, Keiko
AU  - Kudo K
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 
      Minami-kogushi, Ube, Yamaguchi 755-8505, Japan. kkkkeiko@yamaguchi-u.ac.jp
FAU - Hasegawa, Shunji
AU  - Hasegawa S
FAU - Suzuki, Yasuo
AU  - Suzuki Y
FAU - Hirano, Reiji
AU  - Hirano R
FAU - Wakiguchi, Hiroyuki
AU  - Wakiguchi H
FAU - Kittaka, Setsuaki
AU  - Kittaka S
FAU - Ichiyama, Takashi
AU  - Ichiyama T
LA  - eng
PT  - Journal Article
DEP - 20120725
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (dihydroxy-vitamin D3)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Cell Adhesion/drug effects
MH  - Coronary Vessels/*cytology
MH  - Endothelial Cells/drug effects/metabolism
MH  - Endothelium, Vascular/cytology
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Interleukin-6/metabolism
MH  - Interleukin-8/genetics/*metabolism
MH  - Mucocutaneous Lymph Node Syndrome/drug therapy
MH  - RNA, Messenger/drug effects/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism/pharmacology
MH  - Vascular Cell Adhesion Molecule-1/genetics/*metabolism
MH  - Vitamin D/*analogs & derivatives/pharmacology
EDAT- 2012/07/31 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/05/11 00:00 [received]
PHST- 2012/07/11 00:00 [revised]
PHST- 2012/07/17 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - S0960-0760(12)00139-2 [pii]
AID - 10.1016/j.jsbmb.2012.07.003 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2012 Nov;132(3-5):290-4. doi: 
      10.1016/j.jsbmb.2012.07.003. Epub 2012 Jul 25.