PMID- 22841916
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20231213
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 64
DP  - 2013 Jan
TI  - Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal 
      BDNF immunocontent in middle-aged rats.
PG  - 153-9
LID - S0028-3908(12)00345-0 [pii]
LID - 10.1016/j.neuropharm.2012.07.010 [doi]
AB  - Beneficial effects of caffeine on memory processes have been observed in animal 
      models relevant to neurodegenerative diseases and aging, although the underlying 
      mechanisms remain unknown. Because brain-derived neurotrophic factor (BDNF) is 
      associated with memory formation and BDNF's actions are modulated by adenosine 
      receptors, the molecular targets for the psychostimulant actions of caffeine, we 
      here compare the effects of chronic caffeine (1 mg/mL drinking solution for 30 
      days) on short- and long term memory and on levels of hippocampal proBDNF, mature 
      BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats. 
      Caffeine treatment substantially reduced i) age-related impairments in the two 
      types of memory in an inhibitory avoidance paradigm, and ii) parallel increases 
      in hippocampal BDNF levels. In addition, chronic caffeine increased proBDNF and 
      CREB concentrations, and decreased TrkB levels, in hippocampus regardless of age. 
      These data provide new evidence in favor of the hypothesis that modifications in 
      BDNF and related proteins in the hippocampus contribute to the pro-cognitive 
      effects of caffeine on age-associated losses in memory encoding. This article is 
      part of a Special Issue entitled 'Cognitive Enhancers'.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Sallaberry, Cassia
AU  - Sallaberry C
AD  - Laboratory of Studies on the Purinergic System, Department of Biochemistry, 
      Health and Basic Sciences Institute, Federal University of Rio Grande do Sul, Rua 
      Ramiro Barcelos, 2600-anexo, Porto Alegre, RS 90035 003, Brazil.
FAU - Nunes, Fernanda
AU  - Nunes F
FAU - Costa, Marcelo S
AU  - Costa MS
FAU - Fioreze, Gabriela T
AU  - Fioreze GT
FAU - Ardais, Ana Paula
AU  - Ardais AP
FAU - Botton, Paulo Henrique S
AU  - Botton PH
FAU - Klaudat, Bruno
AU  - Klaudat B
FAU - Forte, Thomas
AU  - Forte T
FAU - Souza, Diogo O
AU  - Souza DO
FAU - Elisabetsky, Elaine
AU  - Elisabetsky E
FAU - Porciuncula, Lisiane O
AU  - Porciuncula LO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120727
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, rat)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Nootropic Agents)
RN  - 0 (Protein Precursors)
RN  - 0 (brain-derived neurotrophic factor precursor)
RN  - 3G6A5W338E (Caffeine)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Avoidance Learning
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Caffeine/*therapeutic use
MH  - Central Nervous System Stimulants/therapeutic use
MH  - Cognitive Dysfunction/metabolism/*prevention & control
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Hippocampus/growth & development/*metabolism
MH  - Male
MH  - Memory, Long-Term
MH  - Memory, Short-Term
MH  - Neural Inhibition
MH  - Neurons/*metabolism
MH  - Nootropic Agents/*therapeutic use
MH  - Protein Precursors/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/metabolism
EDAT- 2012/07/31 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/04/01 00:00 [received]
PHST- 2012/07/03 00:00 [revised]
PHST- 2012/07/04 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - S0028-3908(12)00345-0 [pii]
AID - 10.1016/j.neuropharm.2012.07.010 [doi]
PST - ppublish
SO  - Neuropharmacology. 2013 Jan;64:153-9. doi: 10.1016/j.neuropharm.2012.07.010. Epub 
      2012 Jul 27.