PMID- 22842081
OWN - NLM
STAT- MEDLINE
DCOM- 20130102
LR  - 20120820
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1472
DP  - 2012 Sep 7
TI  - Caloric restriction improves basal redox parameters in hippocampus and cerebral 
      cortex of Wistar rats.
PG  - 11-9
LID - 10.1016/j.brainres.2012.07.021 [doi]
AB  - Caloric restriction (CR) has been shown to either decrease or prevent the 
      progression of several age-related pathologies. In previous work, we demonstrated 
      that CR modulates astrocyte functions, suggesting that CR may exert neuroglial 
      modulation. Here, we investigated the effects of CR on hippocampal (Hc) and 
      cortical (Cx) oxidative stress parameters of male Wistar rats. Our results showed 
      that CR-fed rats had 17% less body weight gain after 12 weeks of treatment. CR 
      improved locomotion performance, increased glutathione levels and decreased 
      glutathione peroxidase activity and the production of reactive oxygen species. 
      However, no changes were observed in lipid peroxidation, nitric oxide content and 
      catalase activity. Single cell gel electrophoresis assay (comet assay) revealed a 
      reduction in the extent of basal DNA damage upon CR. Our data suggest that 
      dietary CR could induce both hippocampal and cortical modulation resulting in 
      metabolic changes and as a consequence, significant improvement of cellular 
      defense-associated parameters.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Ribeiro, Leticia C
AU  - Ribeiro LC
AD  - Research Group in Neuroglial Plasticity, Department of Biochemistry, Federal 
      University of Rio Grande do Sul, Porto Alegre, RS, Brazil. 
      leticia.ribeiro@ufsc.br
FAU - Rodrigues, Leticia
AU  - Rodrigues L
FAU - Quincozes-Santos, Andre
AU  - Quincozes-Santos A
FAU - Tramontina, Ana C
AU  - Tramontina AC
FAU - Bambini-Junior, Victorio
AU  - Bambini-Junior V
FAU - Zanotto, Caroline
AU  - Zanotto C
FAU - Diehl, Luisa A
AU  - Diehl LA
FAU - Biasibetti, Regina
AU  - Biasibetti R
FAU - Kleinkauf-Rocha, Juliana
AU  - Kleinkauf-Rocha J
FAU - Dalmaz, Carla
AU  - Dalmaz C
FAU - Goncalves, Carlos-Alberto
AU  - Goncalves CA
FAU - Gottfried, Carmem
AU  - Gottfried C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - *Caloric Restriction
MH  - Cerebral Cortex/*metabolism
MH  - Comet Assay
MH  - DNA Damage
MH  - Male
MH  - Motor Activity/physiology
MH  - Oxidation-Reduction
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
EDAT- 2012/07/31 06:00
MHDA- 2013/01/03 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/02/27 00:00 [received]
PHST- 2012/06/29 00:00 [revised]
PHST- 2012/07/12 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/03 06:00 [medline]
AID - S0006-8993(12)01168-7 [pii]
AID - 10.1016/j.brainres.2012.07.021 [doi]
PST - ppublish
SO  - Brain Res. 2012 Sep 7;1472:11-9. doi: 10.1016/j.brainres.2012.07.021. Epub 2012 
      Jul 24.