PMID- 22842703
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20211021
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 14
IP  - 5
DP  - 2012 Sep
TI  - Sperm counts and sperm sex ratio in male infertility patients.
PG  - 683-6
LID - 10.1038/aja.2012.58 [doi]
AB  - In recent years, investigators have noted a trend toward a declining proportion 
      of male births in many industrialized nations. While men bear the sex-determining 
      chromosome, the role of the female partner as it pertains to fertilization or 
      miscarriage may also alter the gender ratio. We attempted to determine a man's 
      secondary sex ratio (F1 generation) by directly examining the sex chromosomes of 
      his sperm. We examined our male infertility clinic database for all men who had 
      undergone a semen fluorescence in situ hybridization (FISH). Patient demographic 
      and semen parameters were recorded. Chi-squared analysis was used to compare 
      gender ratios (Y chromosomes/total chromosomes). Multivariable logistic 
      regression was used to predict the odds of possessing a Y-bearing sperm after 
      accounting for demographic and semen parameters. A total of 185 men underwent 
      sperm FISH. For the entire cohort, the proportion of Y chromosome-bearing sperm 
      was 51.5%. Men with less than five million motile sperm had a significantly lower 
      proportion of Y chromosome-bearing sperm (50.8%) compared to men with higher 
      sperm counts (51.6%; P=0.02). After multivariable adjustment, a higher sperm 
      concentration, total motile sperm count and semen volume significantly increased 
      the odds of having a Y chromosome-bearing sperm (P<0.01). As a man's sperm 
      production declines, so does the proportion of Y chromosome-bearing sperm. Thus, 
      a man's reproductive potential may predict his ability to sire male offspring.
FAU - Eisenberg, Michael L
AU  - Eisenberg ML
AD  - Department of Urology, Stanford University School of Medicine, Stanford, CA 
      94305, USA. berg@stanford.edu
FAU - Murthy, Lata
AU  - Murthy L
FAU - Hwang, Kathleen
AU  - Hwang K
FAU - Lamb, Dolores J
AU  - Lamb DJ
FAU - Lipshultz, Larry I
AU  - Lipshultz LI
LA  - eng
PT  - Journal Article
DEP - 20120730
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*pathology
MH  - Male
MH  - *Sex Ratio
MH  - *Sperm Count
PMC - PMC3735000
EDAT- 2012/07/31 06:00
MHDA- 2013/01/23 06:00
PMCR- 2012/09/01
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - aja201258 [pii]
AID - 10.1038/aja.2012.58 [doi]
PST - ppublish
SO  - Asian J Androl. 2012 Sep;14(5):683-6. doi: 10.1038/aja.2012.58. Epub 2012 Jul 30.