PMID- 22842811
OWN - NLM
STAT- MEDLINE
DCOM- 20140110
LR  - 20220330
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 36
IP  - 5
DP  - 2013 May
TI  - Association of ELMO1 gene polymorphisms with diabetic nephropathy in Chinese 
      population.
PG  - 298-302
LID - 10.3275/8525 [doi]
AB  - BACKGROUND: Genetic variations in the engulfment and cell motility 1 (ELMO1) gene 
      have recently been identified to be associated with nephropathy attributed to 
      Type 2 diabetes mellitus (T2DM). Since T2DM-associated complications are proved 
      to be more common among Asians than Western individuals, and Chinese people have 
      a high incidence of diabetic nephropathy (DN), this study sought to analyze the 
      association of ELMO1 gene polymorphisms with DN to probe into the effects of 
      ELMO1 gene on susceptibility of DN in Chinese population. METHODS: We genotyped 6 
      polymorphism sites of ELMO1 gene in 200 unrelated Chinese subjects (123 T2DM with 
      DN case subjects and 77 T2DM without DN control subjects). Genotyping was 
      detected by a Sequenom MassARRAY genotyping system. RESULTS: The strongest 
      associations in ELMO1 gene with DN occurred at rs741301 [odds ratio (OR) 1.89; 
      p=0.004] and rs10951509 (OR 1.76; p=0.02). Unconditional logistic regression 
      analysis identified that the rs741301 polymorphism (presence of A allele, 
      adjusted OR 3.27; p=0.03) and duration of T2DM (adjusted OR 1.15; p=0.04) were 
      independent predictors for DN. The marker rs741301 located in intron 18 of ELMO1 
      gene was in strong linkage disequilibrium (LD) with rs11769038 (D'=0.91). 
      Furthermore, haplotype analysis identified that haplotype 1 [CAAAGA] (OR 1.95; 
      p=0.01), haplotype 2 [CAAAGG] (OR 0.50; p=0.01), and haplotype 9 [TGCGGG] (OR 
      0.17; p=0.007) of ELMO1 were significantly associated with DN. CONCLUSIONS: This 
      study first investigated the association of ELMO1 gene polymorphisms with DN in a 
      Chinese population, supporting its key role as a candidate gene in the 
      susceptibility of DN.
FAU - Wu, H Y
AU  - Wu HY
AD  - Department of Endocrinology, Jingzhou First People's Hospital, Yangtze 
      University, 8 Hang-kong street, Jingzhou, Hubei 434000, People's Republic of 
      China. hongyan_wu2003@yahoo.com.cn
FAU - Wang, Y
AU  - Wang Y
FAU - Chen, M
AU  - Chen M
FAU - Zhang, X
AU  - Zhang X
FAU - Wang, D
AU  - Wang D
FAU - Pan, Y
AU  - Pan Y
FAU - Li, L
AU  - Li L
FAU - Liu, D
AU  - Liu D
FAU - Dai, X M
AU  - Dai XM
LA  - eng
PT  - Journal Article
DEP - 20120724
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (ELMO1 protein, human)
SB  - IM
EIN - J Endocrinol Invest. 2013 Jun;36(6):452. Dai, M X [corrected to Dai, X M]; Wu, Y 
      H [corrected to Wu, H Y]
MH  - Adaptor Proteins, Signal Transducing/*genetics/metabolism
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - China
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/blood/*genetics/metabolism
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Introns
MH  - Linkage Disequilibrium
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2012/07/31 06:00
MHDA- 2014/01/11 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2014/01/11 06:00 [medline]
AID - 8525 [pii]
AID - 10.3275/8525 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2013 May;36(5):298-302. doi: 10.3275/8525. Epub 2012 Jul 24.