PMID- 22842820
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20120816
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 6
IP  - 4
DP  - 2012 Oct
TI  - Correlations between cognitive impairment and brain‑derived neurotrophic factor 
      expression in the hippocampus of post-stroke depression rats.
PG  - 889-93
LID - 10.3892/mmr.2012.1009 [doi]
AB  - The aim of this study was to investigate the correlation between brain-derived 
      neurotrophic factor (BDNF) expression and cognitive impairment in post‑stroke 
      depression (PSD) rats and to explore the mechanism(s) involved in the process of 
      cognitive impairment. A rat model of focal cerebral ischemia was established by 
      occluding the middle cerebral artery (MCA). Rats were subjected to 
      isolation-housing combined with chronic unexpected mild stress (CUMS) to 
      establish a PSD rat model. The learning and memory abilities of the PSD rat model 
      were evaluated by passive avoidance tests. Real‑time PCR and immunohistochemical 
      methods were used to detect changes in BDNF mRNA and protein expression in the 
      hippocampus. Passive avoidance defects were revealed in the PSD and depression 
      groups. Passive avoidance defects were more evident in the PSD group compared 
      with the depression group and the difference was statistically significant 
      (P<0.05). BDNF expression in the hippocampus was significantly lower in the PSD 
      and depression groups compared with that in the normal control group (P<0.01). No 
      significant difference in BDNF expression was identified between the normal 
      control and stroke groups (P>0.05) or between the PSD and the depression groups 
      (P>0.05). The decrease in BDNF expression in the hippocampus of PSD rats may 
      aggravate cognitive impairment, however, the degree of cognitive impairment 
      cannot be reflected by the expression levels of BDNF in the hippocampus.
FAU - Zhang, Zhao-Hui
AU  - Zhang ZH
AD  - The Second Affiliated Hospital of Xinxiang Medical University, Henan Key 
      Laboratory of Biological Psychiatry, Xinxiang, PR China.
FAU - Wu, Li-Na
AU  - Wu LN
FAU - Song, Jing-Gui
AU  - Song JG
FAU - Li, Wen-Qiang
AU  - Li WQ
LA  - eng
PT  - Journal Article
DEP - 20120726
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cognition Disorders/*metabolism/pathology
MH  - Depression/etiology/*metabolism
MH  - Disease Models, Animal
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stroke/pathology
EDAT- 2012/07/31 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/03/20 00:00 [received]
PHST- 2012/07/13 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.3892/mmr.2012.1009 [doi]
PST - ppublish
SO  - Mol Med Rep. 2012 Oct;6(4):889-93. doi: 10.3892/mmr.2012.1009. Epub 2012 Jul 26.