PMID- 22843221
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20181201
IS  - 1468-2982 (Electronic)
IS  - 0333-1024 (Linking)
VI  - 32
IP  - 13
DP  - 2012 Oct
TI  - Different trigemino-vascular responsiveness between adolescent and adult rats in 
      a migraine model.
PG  - 979-90
AB  - BACKGROUND: Pediatric migraine displays different clinical features from adult 
      migraine. Because the trigemino-vascular system (TGVS) plays a pivotal role in 
      migraine pathophysiology, this study compared TGVS responses in a migraine model 
      induced by intracisternal (i.c.) instillation of capsaicin in adolescent and 
      adult rats. METHODS: TGVS responses measured included c-Fos-protein-expressing 
      neurons in the trigeminal cervical complex (TCC), calcitonin gene-related peptide 
      (CGRP) expression in the trigeminal ganglia (TG) and dura mater, and dural 
      protein extravasation. The formulas for estimating total numbers of activated TCC 
      neurons were established based on the c-Fos-positive neuronal numbers in three 
      sample sections, +0.6, -1.2 and -9 mm and +0.6, -0.6 and -6 mm, from the obex in 
      adult and adolescent rats, respectively. RESULTS: After capsaicin instillation, 
      adolescent rats had comparable TCC neurons activated as adult rats, but less TGVS 
      peripheral responsiveness than adults, including CGRP immunoreactivity in the TG, 
      and protein extravasation and CGRP depletion (inversely reflected by CGRP 
      immunoreactivity) in the dura mater. CONCLUSIONS: Age-dependent differences in 
      TGVS responsiveness in the i.c. capsaicin-induced migraine model of rats are 
      reminiscent of less severe migraine in pediatric patients. This finding may 
      provide new insight into the pathophysiology of migraine and guide the 
      development of new anti-migraine drugs for children.
FAU - Fan, Pi-Chuan
AU  - Fan PC
AD  - Graduate Institute of Pharmacology, College of Medicine, National Taiwan 
      University, No. 1 Jen-Ai Rd., Taipei 100, Taiwan.
FAU - Kuo, Ping-Hung
AU  - Kuo PH
FAU - Hu, James W
AU  - Hu JW
FAU - Chang, Shu-Hui
AU  - Chang SH
FAU - Hsieh, Sung-Tsang
AU  - Hsieh ST
FAU - Chiou, Lih-Chu
AU  - Chiou LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120726
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (Irritants)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Calcitonin Gene-Related Peptide/analysis/biosynthesis
MH  - Capsaicin/toxicity
MH  - Disease Models, Animal
MH  - Dura Mater/blood supply/metabolism
MH  - Immunohistochemistry
MH  - Irritants/toxicity
MH  - Male
MH  - Migraine Disorders/metabolism/pathology/*physiopathology
MH  - Neurons/*metabolism/pathology
MH  - Proto-Oncogene Proteins c-fos/analysis/biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Trigeminal Ganglion/metabolism/*physiopathology
EDAT- 2012/07/31 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 0333102412455710 [pii]
AID - 10.1177/0333102412455710 [doi]
PST - ppublish
SO  - Cephalalgia. 2012 Oct;32(13):979-90. doi: 10.1177/0333102412455710. Epub 2012 Jul 
      26.