PMID- 22844024
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20211021
IS  - 1472-1465 (Electronic)
IS  - 0007-1250 (Print)
IS  - 0007-1250 (Linking)
VI  - 201
IP  - 4
DP  - 2012 Oct
TI  - Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol 
      levels as a predictor of depression in adult women.
PG  - 313-9
LID - 10.1192/bjp.bp.111.107037 [doi]
AB  - BACKGROUND: Common genetic variants, such as the brain-derived neurotrophic 
      factor (BDNF) Val/66/Met polymorphism (rs6265), are known to interact with 
      environmental factors such as early adversity to increase the risk of subsequent 
      major depression. Much less is known about how they interact with individual 
      differences in cortisol, although these also represent a risk for major 
      depression. AIMS: To determine whether this BDNF variant moderated the risk 
      represented by higher levels of morning salivary cortisol in adult women. METHOD: 
      We recruited 279 premenopausal women who were at high risk of major depressive 
      disorder because of either negative self-evaluation, unsupportive core 
      relationship or chronic subclinical symptoms of depression or anxiety. Morning 
      salivary cortisol was measured daily for up to 10 days at entry. Participants 
      were followed up for about 12 months by telephone calls at 3-4 monthly intervals. 
      Major depression and severe life events were assessed through interviews at 
      baseline and follow-up; DNA was obtained from the saliva. RESULTS: There were 53 
      onsets (19%) of depressive episodes during follow-up. There was a significant 
      U-shaped relationship between adjusted morning cortisol levels at baseline and 
      the probability of depression onset during follow-up. In total, 51% experienced 
      at least one severe life event/difficulty, and this strongly predicted subsequent 
      onsets of depressive episodes. The BDNF Val/66/Met genotype was not directly 
      associated with onsets of depression or with cortisol levels, but there was 
      significant interaction between Val/66/Met and cortisol: the association between 
      baseline cortisol and depression was limited to those with the Val/66/Val 
      variant. There was no interaction between life events and either this BDNF 
      polymorphism or cortisol levels. CONCLUSIONS: Morning salivary cortisol interacts 
      with the BDNF Val/66/Met polymorphism in predicting new depressive episodes. This 
      paper adds to the evidence that single gene polymorphisms interact with 
      endogenous factors to predict depression.
FAU - Herbert, J
AU  - Herbert J
AD  - Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, 
      University of Cambridge, Cambridge CB2 0SP, UK. jh24@cam.ac.uk
FAU - Ban, M
AU  - Ban M
FAU - Brown, G W
AU  - Brown GW
FAU - Harris, T O
AU  - Harris TO
FAU - Ogilvie, A
AU  - Ogilvie A
FAU - Uher, R
AU  - Uher R
FAU - Craig, T K J
AU  - Craig TK
LA  - eng
GR  - 066693/Z/01/Z/Wellcome Trust/United Kingdom
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120726
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Anxiety/genetics/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder, Major/diagnosis/*genetics/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease/genetics/*psychology
MH  - Humans
MH  - Hydrocortisone/*metabolism
MH  - Life Change Events
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Saliva/metabolism
PMC - PMC3461447
COIS- Declaration of interest None.
EDAT- 2012/07/31 06:00
MHDA- 2013/03/06 06:00
PMCR- 2013/04/01
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - S0007125000272589 [pii]
AID - 10.1192/bjp.bp.111.107037 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2012 Oct;201(4):313-9. doi: 10.1192/bjp.bp.111.107037. Epub 2012 
      Jul 26.