PMID- 22844355
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Aug
TI  - A unique cytogenetic abnormality, t(2;7)(p13.1;p21.3), in a Philadelphia-positive 
      chronic myeloid leukemia.
PG  - 209-212
AB  - The Philadelphia (Ph) chromosome is present in more than 90% of patients 
      suffering from chronic myeloid leukemia (CML). It is the product of a reciprocal 
      translocation between the long arms of chromosomes 9 and 22, resulting in the 
      transfer of the 3' portion of the proto-oncogene ABL from 9q34 to the 5' portion 
      of the breakpoint cluster region (BCR) on 22q11. Currently, most CML cases are 
      treated with Imatinib and variant rearrangements are thought to have no specific 
      prognostic significance, although the events of therapy resistance have not yet 
      been studied. In this study we report a novel case of CML exhibiting an uncommon 
      t(2;7)(p13.1;p21.3) besides t(9;22)(q34;q11). This unusual translocation has been 
      characterized by fluorescence in situ hybridization (FISH) and array-proven 
      multicolor banding (aMCB), the latter being extremely significant in 
      characterizing breakpoint regions in detail. The underlying mechanisms and 
      prognostic implications of this cytogenetic abnormality are discussed in this 
      study.
FAU - Al-Achkar, Walid
AU  - Al-Achkar W
AD  - Department of Molecular Biology and Biotechnology, Human Genetics Division, 
      Atomic Energy Commission, Damascus, Syria.
FAU - Wafa, Abdulsamad
AU  - Wafa A
FAU - Moassass, Faten
AU  - Moassass F
FAU - Liehr, Thomas
AU  - Liehr T
LA  - eng
PT  - Journal Article
DEP - 20120517
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3402735
EDAT- 2012/07/31 06:00
MHDA- 2012/07/31 06:01
PMCR- 2013/08/01
CRDT- 2012/07/31 06:00
PHST- 2011/10/17 00:00 [received]
PHST- 2012/02/29 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/07/31 06:01 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - ol-04-02-0209 [pii]
AID - 10.3892/ol.2012.720 [doi]
PST - ppublish
SO  - Oncol Lett. 2012 Aug;4(2):209-212. doi: 10.3892/ol.2012.720. Epub 2012 May 17.