PMID- 22844555
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2005-1212 (Electronic)
IS  - 1976-2283 (Print)
IS  - 1976-2283 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Jul
TI  - The current strategy for managing pancreatic neuroendocrine tumors in multiple 
      endocrine neoplasia type 1.
PG  - 287-94
LID - 10.5009/gnl.2012.6.3.287 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an inherited autosomal dominant 
      disease presenting with pancreatic neuroendocrine tumors (pNETs), parathyroid 
      tumors, or pituitary tumors. Using the PubMed database, we reviewed the 
      literature on information regarding the proper diagnosis and treatment of 
      MEN1-associated pNET. Many cases of MEN1-associated pNET are functioning pNETs. 
      Gastrinomas and insulinomas tend to occur frequently in the duodenum and 
      pancreas, respectively. In addition to diagnostic imaging, the selective arterial 
      secretagogue injection test (SASI test) is useful for localizing functioning 
      pNET. The standard treatment is surgical resection. However, in the case of a 
      functioning pNET, the tumor should first be accurately located using the SASI 
      test before an appropriate surgical method is selected. In cases of a 
      MEN1-associated non-functioning pNET that exceeds 2 cm in diameter, the incidence 
      of distant metastasis is significantly increased, and surgery is recommended. In 
      cases of unresectable pNET, a somatostatin analog has been shown to demonstrate 
      antitumor effects and is considered to be a promising treatment. In addition, 
      molecular-targeted drugs have recently been found to be effective in phase III 
      clinical trials.
FAU - Niina, Yusuke
AU  - Niina Y
AD  - Department of Medicine and Bioregulatory Science, Kyushu University Graduate 
      School of Medical Sciences, Fukuoka, Japan.
FAU - Fujimori, Nao
AU  - Fujimori N
FAU - Nakamura, Taichi
AU  - Nakamura T
FAU - Igarashi, Hisato
AU  - Igarashi H
FAU - Oono, Takamasa
AU  - Oono T
FAU - Nakamura, Kazuhiko
AU  - Nakamura K
FAU - Kato, Masaki
AU  - Kato M
FAU - Jensen, Robert T
AU  - Jensen RT
FAU - Ito, Tetsuhide
AU  - Ito T
FAU - Takayanagi, Ryoichi
AU  - Takayanagi R
LA  - eng
PT  - Journal Article
DEP - 20120119
PL  - Korea (South)
TA  - Gut Liver
JT  - Gut and liver
JID - 101316452
PMC - PMC3404164
OTO - NOTNLM
OT  - Multiple endocrine neoplasia type 1
OT  - Multiple tumors
OT  - Pancreatic neuroendocrine tumor
OT  - Selective arterial secretagogue injection test
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2012/07/31 06:00
MHDA- 2012/07/31 06:01
PMCR- 2012/07/01
CRDT- 2012/07/31 06:00
PHST- 2011/08/01 00:00 [received]
PHST- 2011/09/27 00:00 [revised]
PHST- 2011/09/28 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/07/31 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 10.5009/gnl.2012.6.3.287 [doi]
PST - ppublish
SO  - Gut Liver. 2012 Jul;6(3):287-94. doi: 10.5009/gnl.2012.6.3.287. Epub 2012 Jan 19.