PMID- 22845683
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20220318
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 39
IP  - 10
DP  - 2012 Oct
TI  - Desmoplastic melanocytic nevi with lymphocytic aggregates.
PG  - 940-4
LID - 10.1111/j.1600-0560.2012.01962.x [doi]
AB  - Desmoplastic melanocytic nevi can be difficult to distinguish from desmoplastic 
      melanoma. The presence of lymphocytic aggregates in association with a sclerosing 
      melanocytic proliferation is commonly regarded as a feature in support of a 
      diagnosis of desmoplastic melanoma. However, the finding is not specific for 
      melanoma. Herein we report six cases of sclerosing melanocytic nevi with 
      associated lymphocytic aggregates. They occurred in five women and one man, 
      ranging in age from 11 to 61 years. Three lesions were sclerosing Spitz nevi; one 
      was an amelanotic sclerosing blue nevus, one an acquired intradermal sclerosing 
      nevus, and one was a congenital compound melanocytic nevus with sclerosis of its 
      dermal component. The lesions were interpreted as benign, i.e. melanocytic nevi, 
      because of their histopathologic attributes (symmetric silhouette, benign 
      cytologic features) and results from immunohistochemical studies (all lesions 
      strongly expressed Melan-A and p16) and fluorescence in situ hybridization 
      (FISH). Three lesions tested by FISH lacked copy number changes of 11p, 6q or 6p. 
      None of the lesions recurred. The cases highlight that contextual information is 
      essential for the diagnosis of desmoplastic melanoma and sclerosing nevus. The 
      presence of lymphocytic aggregates per se does not prove that a sclerosing 
      melanocytic proliferation is malignant.
CI  - Copyright (c) 2012 John Wiley & Sons A/S.
FAU - Kiuru, Maija
AU  - Kiuru M
AD  - Department of Dermatology, Weill Medical College of Cornell University, New York, 
      NY, USA.
FAU - Patel, Rajiv M
AU  - Patel RM
FAU - Busam, Klaus J
AU  - Busam KJ
LA  - eng
PT  - Journal Article
DEP - 20120728
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes/immunology/*pathology
MH  - Male
MH  - Melanoma/immunology/*pathology
MH  - Middle Aged
MH  - Nevus, Pigmented/immunology/*pathology
MH  - Skin Neoplasms/immunology/*pathology
MH  - Young Adult
EDAT- 2012/08/01 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/05/25 00:00 [revised]
PHST- 2012/06/26 00:00 [accepted]
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - 10.1111/j.1600-0560.2012.01962.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 2012 Oct;39(10):940-4. doi: 10.1111/j.1600-0560.2012.01962.x. 
      Epub 2012 Jul 28.