PMID- 22848309
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 2
IP  - 6
DP  - 2011 Nov
TI  - Expression of MMP-3 and TIMP-3 in gastric cancer tissue and its clinical 
      significance.
PG  - 1319-1322
AB  - The present study aimed to investigate the expression of matrix 
      metalloproteinase-3 (MMP-3) and the tissue inhibitor of metalloproteinase-3 
      (TIMP-3) in gastric cancer tissue, as well as to analyze the correlation between 
      their expression and the occurrence of gastric cancer. Immunohistochemistry was 
      used to determine the expression of MMP-3 and TIMP-3 in the gastric cancer tissue 
      from 18 patients with early-stage gastric cancer (early-stage group) and 26 
      patients with advanced-stage gastric cancer (advanced-stage group). Transmission 
      electron microscopy (TEM) was used to observe the lymphocytes and tumor cells in 
      gastric cancer tissue. The results showed that the expression of TIMP-3 was 
      significantly higher, whereas that of MMP-3 and MMP-3/TIMP-3 was lower in gastric 
      cancer tissue of the early-stage group than in that of the advanced-stage group 
      (P<0.05). The TEM images revealed increased lymphocytes and inconspicuous tumor 
      cells penetrating the basement membrane in gastric cancer tissue of the 
      early-stage group, and decreased lymphocytes and obvious tumor cells penetrating 
      the basement membrane in the advanced-stage group. In conclusion, MMP-3 and 
      TIMP-3 may be used as indices for the invasion and metastasis of gastric cancer 
      and possess marked clinical significance in the prognostic judgment of gastric 
      cancer.
FAU - Liu, Hong-Qi
AU  - Liu HQ
AD  - Department of Oncology, Yancheng First People's Hospital, Yancheng 224005.
FAU - Song, Shu
AU  - Song S
FAU - Wang, Jian-Hua
AU  - Wang JH
FAU - Zhang, Shao-Lan
AU  - Zhang SL
LA  - eng
PT  - Journal Article
DEP - 20110831
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3406489
EDAT- 2012/08/01 06:00
MHDA- 2012/08/01 06:01
PMCR- 2011/08/31
CRDT- 2012/08/01 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2011/08/19 00:00 [accepted]
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/08/01 06:01 [medline]
PHST- 2011/08/31 00:00 [pmc-release]
AID - ol-02-06-1319 [pii]
AID - 10.3892/ol.2011.399 [doi]
PST - ppublish
SO  - Oncol Lett. 2011 Nov;2(6):1319-1322. doi: 10.3892/ol.2011.399. Epub 2011 Aug 31.