PMID- 22848834
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20220129
IS  - 2090-2832 (Electronic)
IS  - 2090-2824 (Print)
IS  - 2090-2824 (Linking)
VI  - 2012
DP  - 2012
TI  - Anti-inflammatory effects of epoxyeicosatrienoic acids.
PG  - 605101
LID - 10.1155/2012/605101 [doi]
LID - 605101
AB  - Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective 
      and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and 
      inactivated largely by soluble epoxide hydrolase (sEH), which converts them to 
      their corresponding dihydroxyeicosatrienoic acids (DHETs). EETs have been shown 
      to have a diverse range of effects on the vasculature including relaxation of 
      vascular tone, cellular proliferation, and angiogenesis as well as the migration 
      of smooth muscle cells. This paper will highlight the growing evidence that EETs 
      also mediate a number of anti-inflammatory effects in the cardiovascular system. 
      In particular, numerous studies have demonstrated that potentiation of EET 
      activity using different methods can inhibit inflammatory gene expression and 
      signalling pathways in endothelial cells and monocytes and in models of 
      cardiovascular diseases. The mechanisms by which EETs mediate their effects are 
      largely unknown but may include direct binding to peroxisome 
      proliferator-activated receptors (PPARs), G-protein coupled receptors (GPCRs), or 
      transient receptor potential (TRP) channels, which initiate anti-inflammatory 
      signalling cascades.
FAU - Thomson, Scott J
AU  - Thomson SJ
AD  - Translational Medicine and Therapeutics, William Harvey Research Institute, Barts 
      and The London School of Medicine and Dentistry, Queen Mary University of London, 
      Charterhouse Square, London EC1M 6BQ, UK.
FAU - Askari, Ara
AU  - Askari A
FAU - Bishop-Bailey, David
AU  - Bishop-Bailey D
LA  - eng
GR  - PG/11/39/28890/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
DEP - 20120716
PL  - United States
TA  - Int J Vasc Med
JT  - International journal of vascular medicine
JID - 101542608
PMC - PMC3405717
EDAT- 2012/08/01 06:00
MHDA- 2012/08/01 06:01
PMCR- 2012/07/16
CRDT- 2012/08/01 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/06/20 00:00 [accepted]
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/08/01 06:01 [medline]
PHST- 2012/07/16 00:00 [pmc-release]
AID - 10.1155/2012/605101 [doi]
PST - ppublish
SO  - Int J Vasc Med. 2012;2012:605101. doi: 10.1155/2012/605101. Epub 2012 Jul 16.