PMID- 22850733
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20211021
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 37
IP  - 12
DP  - 2012 Nov
TI  - Investigation of cortical glutamate-glutamine and gamma-aminobutyric acid in 
      obsessive-compulsive disorder by proton magnetic resonance spectroscopy.
PG  - 2684-92
LID - 10.1038/npp.2012.132 [doi]
AB  - Glutamatergic abnormalities in corticostriatal brain circuits are thought to 
      underlie obsessive-compulsive disorder (OCD). Whether these abnormalities exist 
      in adults with OCD is not clear. We used proton magnetic resonance spectroscopy 
      ((1)H MRS) to test our hypothesis that unmedicated adults with OCD have reduced 
      glutamate plus glutamine (Glx) levels in the medial prefrontal cortex (MPFC) 
      compared with healthy controls. Levels of gamma-aminobutyric acid (GABA) were also 
      explored. Twenty-four unmedicated adults with OCD and 22 matched healthy control 
      subjects underwent (1)H MRS scans at 3.0 T. Resonances of both Glx and GABA were 
      obtained using the standard J-editing technique and assessed as ratios relative 
      to voxel tissue water (W) in the MPFC (the region of interest) and the 
      dorsolateral prefrontal cortex (DLPFC) to explore the regional specificity of any 
      finding. In the MPFC, Glx/W did not differ by diagnostic group (p=0.98) or sex 
      (p=0.57). However, GABA/W was decreased in OCD (2.16+/-0.46 x 10(-)(3)) compared with 
      healthy controls (2.43+/-0.45 x 10(-)(3), p=0.045); moreover, age of OCD onset was 
      inversely correlated with MPFC GABA/W (r=-0.50, p=0.015). MPFC GABA/W was higher 
      in females than in males. In the DLPFC, there were no main effects of diagnosis 
      or gender on Glx/W or GABA/W. These data indicate that unmedicated adults with 
      OCD do not have Glx abnormalities in a MPFC voxel that includes the pregenual 
      anterior cingulate cortex. However, they may have decreased MPFC GABA levels. How 
      GABA abnormalities might contribute to corticostriatal dysfunction in OCD 
      deserves further study.
FAU - Simpson, Helen B
AU  - Simpson HB
AD  - Department of Psychiatry at Columbia University, College of Physicians and 
      Surgeons, New York, NY 10032, USA. simpson@nyspi.columbia.edu
FAU - Shungu, Dikoma C
AU  - Shungu DC
FAU - Bender, James Jr
AU  - Bender J Jr
FAU - Mao, Xiangling
AU  - Mao X
FAU - Xu, Xiaoyan
AU  - Xu X
FAU - Slifstein, Mark
AU  - Slifstein M
FAU - Kegeles, Lawrence S
AU  - Kegeles LS
LA  - eng
GR  - K24 MH091555/MH/NIMH NIH HHS/United States
GR  - R01 MH073915/MH/NIMH NIH HHS/United States
GR  - R01 MH075895/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120801
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0RH81L854J (Glutamine)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Brain Chemistry/physiology
MH  - Cerebral Cortex/*metabolism/*pathology
MH  - Data Interpretation, Statistical
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Glutamic Acid/*metabolism
MH  - Glutamine/*metabolism
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Obsessive-Compulsive Disorder/*metabolism/*pathology/psychology
MH  - Young Adult
MH  - gamma-Aminobutyric Acid/*metabolism
PMC - PMC3473334
EDAT- 2012/08/02 06:00
MHDA- 2013/03/23 06:00
PMCR- 2013/11/01
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - npp2012132 [pii]
AID - 10.1038/npp.2012.132 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2012 Nov;37(12):2684-92. doi: 10.1038/npp.2012.132. Epub 
      2012 Aug 1.