PMID- 22854676
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20121011
IS  - 1421-9891 (Electronic)
IS  - 1022-6877 (Linking)
VI  - 18
IP  - 6
DP  - 2012
TI  - Altered serum levels of brain-derived neurotrophic factor in patients with 
      pathological gambling.
PG  - 297-301
LID - 10.1159/000338281 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays important roles in 
      neurotransmitter release and synaptic plasticity and has been hypothesized to be 
      involved in the development and maintenance of addictive disorders. The objective 
      of this study was to investigate alterations of BDNF expression in a 
      non-substance-related addiction, i.e. pathological gambling (PG). METHODS: Serum 
      levels of BDNF were assessed in male patients with PG (n = 14) and healthy 
      control subjects (n = 13) carefully matched for sex, age, body mass index, 
      smoking status and urbanicity. Symptoms and severity of PG were measured by the 
      adapted form of the Yale-Brown Obsessive-Compulsive Scale. RESULTS: BDNF serum 
      levels were significantly increased in patients with PG in comparison to healthy 
      control subjects (p = 0.016). There were no significant correlations between BDNF 
      serum levels and severity of PG or clinical and demographic variables. 
      CONCLUSIONS: Our results show alterations of BDNF serum levels in patients 
      suffering from a behavioural addiction and suggest that non-substance-related 
      addictions like PG might be associated with neuroendocrinological changes similar 
      to the changes observed in substance-related addictions.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Geisel, Olga
AU  - Geisel O
AD  - Department of Psychiatry, Campus Charite Mitte, Charite - Universitatsmedizin 
      Berlin, Berlin, Germany.
FAU - Banas, Roman
AU  - Banas R
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Muller, Christian A
AU  - Muller CA
LA  - eng
PT  - Journal Article
DEP - 20120731
PL  - Switzerland
TA  - Eur Addict Res
JT  - European addiction research
JID - 9502920
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - Gambling/*blood
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - Severity of Illness Index
EDAT- 2012/08/03 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/02/02 00:00 [received]
PHST- 2012/03/22 00:00 [accepted]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 000338281 [pii]
AID - 10.1159/000338281 [doi]
PST - ppublish
SO  - Eur Addict Res. 2012;18(6):297-301. doi: 10.1159/000338281. Epub 2012 Jul 31.