PMID- 22855722
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1943-0264 (Electronic)
IS  - 1943-0264 (Linking)
VI  - 4
IP  - 8
DP  - 2012 Aug 1
TI  - Dendritic cells: arbiters of immunity and immunological tolerance.
PG  - a007401
LID - 10.1101/cshperspect.a007401 [doi]
LID - a007401
AB  - Dendritic cells (DCs) link innate immune sensing of the environment to the 
      initiation of adaptive immune responses. Given their supreme capacity to interact 
      with and present antigen to T cells, DCs have been proposed as key mediators of 
      immunological tolerance in the steady state. However, recent evidence suggests 
      that the role of DCs in central and peripheral T-cell tolerance is neither 
      obligate nor dominant. Instead, DCs appear to regulate multiple aspects of T-cell 
      physiology including tonic antigen receptor signaling, priming of effector T-cell 
      response, and the maintenance of regulatory T cells. These diverse contributions 
      of DCs may reflect the significant heterogeneity and "division of labor" observed 
      between and within distinct DC subsets. The emerging complex role of different DC 
      subsets should form the conceptual basis of DC-based therapeutic approaches 
      toward induction of tolerance or immunization.
FAU - Lewis, Kanako L
AU  - Lewis KL
AD  - Department of Microbiology and Immunology, Columbia University Medical Center, 
      New York, New York, 10032, USA.
FAU - Reizis, Boris
AU  - Reizis B
LA  - eng
GR  - R37 AI072571/AI/NIAID NIH HHS/United States
GR  - AI072571/AI/NIAID NIH HHS/United States
GR  - AI007161/AI/NIAID NIH HHS/United States
GR  - T32 AI007161/AI/NIAID NIH HHS/United States
GR  - R01 AI072571/AI/NIAID NIH HHS/United States
GR  - R21 AI085439/AI/NIAID NIH HHS/United States
GR  - AI085439/AI/NIAID NIH HHS/United States
GR  - AI067804/AI/NIAID NIH HHS/United States
GR  - R21 AI067804/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120801
PL  - United States
TA  - Cold Spring Harb Perspect Biol
JT  - Cold Spring Harbor perspectives in biology
JID - 101513680
SB  - IM
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Immunity, Cellular/*immunology
MH  - Signal Transduction/*immunology
MH  - T-Lymphocytes/immunology/*physiology
PMC - PMC3405856
EDAT- 2012/08/03 06:00
MHDA- 2012/12/12 06:00
PMCR- 2014/08/01
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - 4/8/a007401 [pii]
AID - a007401 [pii]
AID - 10.1101/cshperspect.a007401 [doi]
PST - epublish
SO  - Cold Spring Harb Perspect Biol. 2012 Aug 1;4(8):a007401. doi: 
      10.1101/cshperspect.a007401.