PMID- 22856871
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20221207
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 16
IP  - 9
DP  - 2012 Sep
TI  - Influence of brain-derived neurotrophic factor genetic polymorphisms on the ages 
      of onset for heroin dependence in a Chinese population.
PG  - 1044-50
LID - 10.1089/gtmb.2012.0016 [doi]
AB  - AIM: The study aims at evaluating the association between brain-derived 
      neurotrophic factor (BDNF) gene polymorphisms and heroin-dependent patients in 
      the Chinese population. Three polymorphisms of the BDNF-gene (rs10835210, 
      rs16917234, and rs6265) in 486 heroin-dependent patients and in 226 healthy 
      controls were genotyped for analyzing the association of these polymorphisms with 
      age of onset of heroin dependence. We defined the healthy cases as "unknown 
      phenotype" and used the endophenotype (behavior traits) to stratify the heroin 
      dependents group on the basis of self-reporting traits for examining the 
      association between BDNF polymorphisms (rs10835210, rs16917234, and rs6265) and 
      heroin dependence. RESULTS: Allelic distributions of BDNF gene polymorphisms did 
      not differ significantly between heroin-dependent patients and controls. However, 
      we found that the AA carriers of BDNF rs6265 had an earlier onset of heroin 
      dependence and a clearer tendency of family history of heroin-dependent than GG 
      carriers after controlling behavior characteristics across rs6265 genotypes. 
      CONCLUSIONS: Our findings suggested that the BDNF genetic polymorphism (rs6265) 
      may have effects on the age of onset of heroin dependence among the Chinese 
      population. The BDNF gene could contribute to vulnerabilities to heroin 
      dependence.
FAU - Meng, Chao
AU  - Meng C
AD  - College of Life Science, Graduate University of Chinese Academy of Sciences, 
      Beijing, China.
FAU - Lan, Jie
AU  - Lan J
FAU - Wang, Youxin
AU  - Wang Y
FAU - Song, Manshu
AU  - Song M
FAU - Gao, Xuan
AU  - Gao X
FAU - Ran, Longjin
AU  - Ran L
FAU - Moira, Sim
AU  - Moira S
FAU - Wang, Wei
AU  - Wang W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120802
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Heroin Dependence/*epidemiology/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/08/04 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1089/gtmb.2012.0016 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2012 Sep;16(9):1044-50. doi: 10.1089/gtmb.2012.0016. 
      Epub 2012 Aug 2.