PMID- 22857263
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20120924
IS  - 1365-2958 (Electronic)
IS  - 0950-382X (Linking)
VI  - 86
IP  - 1
DP  - 2012 Oct
TI  - Novel insights into genome plasticity in Eukaryotes: mosaic aneuploidy in 
      Leishmania.
PG  - 15-23
LID - 10.1111/j.1365-2958.2012.08185.x [doi]
AB  - Leishmania are unicellular eukaryotes that have many markedly original molecular 
      features compared with other uni- or multicellular eukaryotes like yeasts or 
      mammals. Genome plasticity in this parasite has been the subject of many 
      publications, and has been associated with drug resistance or adaptability. 
      Aneuploidy has been suspected by several authors and it is now confirmed using 
      state-of-the-art technologies such as high-throughput DNA sequencing. The 
      analysis of genome contents at the single cell level using fluorescence in situ 
      hybridization (FISH) has brought a new light on the genome organization: within a 
      cell population, every chromosome, in every cell, may be present in at least two 
      ploidy states (being either monosomic, disomic or trisomic), and the chromosomal 
      content varies greatly from cell to cell, thus generating a constitutive 
      intra-strain genomic heterogeneity, here termed 'mosaic aneuploidy'. Mosaic 
      aneuploidy deeply affects the genetics of these organisms, leading, for example, 
      to an extreme degree of intra-strain genomic diversity, as well as to a clearance 
      of heterozygous cells in the population without however affecting genetic 
      heterogeneity. Second, mosaic aneuploidy might be considered as a powerful 
      strategy evolved by the parasite for adapting to modifications of environment 
      conditions as well as for the emergence of drug resistance. On the whole, mosaic 
      aneuploidy may be considered as a novel mechanism for generating phenotypic 
      diversity driven by genomic plasticity.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Sterkers, Yvon
AU  - Sterkers Y
AD  - Universite Montpellier 1, UFR Medecine, Laboratoire de Parasitologie-Mycologie, 
      Montpellier, France.
FAU - Lachaud, Laurence
AU  - Lachaud L
FAU - Bourgeois, Nathalie
AU  - Bourgeois N
FAU - Crobu, Lucien
AU  - Crobu L
FAU - Bastien, Patrick
AU  - Bastien P
FAU - Pages, Michel
AU  - Pages M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120816
PL  - England
TA  - Mol Microbiol
JT  - Molecular microbiology
JID - 8712028
SB  - IM
MH  - Adaptation, Biological
MH  - *Aneuploidy
MH  - Evolution, Molecular
MH  - Genetic Heterogeneity
MH  - Genome Size
MH  - *Genome, Protozoan
MH  - Genomic Instability
MH  - Leishmania/*genetics
EDAT- 2012/08/04 06:00
MHDA- 2013/01/31 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - 10.1111/j.1365-2958.2012.08185.x [doi]
PST - ppublish
SO  - Mol Microbiol. 2012 Oct;86(1):15-23. doi: 10.1111/j.1365-2958.2012.08185.x. Epub 
      2012 Aug 16.