PMID- 22858370
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20221207
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 89
IP  - 8
DP  - 2012 Nov
TI  - Dioxin-like activity in environmental and human samples from Greenland and 
      Denmark.
PG  - 919-28
LID - 10.1016/j.chemosphere.2012.06.055 [doi]
AB  - Dioxins and dioxin-like (DL) compounds are some of the most toxic chemicals being 
      highly persistent in the environment. The toxicological effects of dioxins are 
      mediated via the aryl hydrocarbon receptor (AhR). Compounds of diverse structure 
      and lipophility can bind and activate AhR. The AhR transactivation bioassay is 
      utilized in an array of projects to study the AhR-mediated activities of 
      individual chemicals and mixtures and for epidemiological purposes. This review 
      summarizes a series of studies regarding the DL-activity of single compounds and 
      complex compound mixtures in the environment and humans. We found that some 
      pesticides, plasticizers and phytoestrogens can activate the AhR, and the 
      combined effect of compounds with no or weak AhR potency cannot be ignored. The 
      significant DL-activity in the wastewater effluent indicates the treatment is not 
      sufficient to prevent contamination of surface waters with dioxins. Our results 
      from human studies suggest that the serum DL-activity reflect the complex mixture 
      of persistent organic pollutants (POPs). Greenlandic Inuit had lower serum 
      DL-activity level compared to Europeans, probably due to long distance from the 
      dioxin sources and UV degradation of the high potent dioxin and/or the inhibitory 
      effect of the high level of non-DL POPs. Selective bioaccumulation of PCBs in the 
      food chain may contribute to the negative correlation between serum POPs and 
      DL-activity observed in Greenlandic Inuit. Hence the AhR transactivation bioassay 
      provides a cost-effective and integrated screening tool for measurement of the 
      DL-activity in human, environmental and commercial samples.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Long, Manhai
AU  - Long M
AD  - Cellular & Molecular Toxicology, Centre of Arctic Health, Department of public 
      Health, Arhus University, 8000 Aarhus C, Denmark. ml@mil.au.dk
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120802
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Waste Water)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Denmark
MH  - Dioxins/*analysis/blood
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*analysis/blood
MH  - Greenland
MH  - Humans
MH  - Polychlorinated Biphenyls/analysis/blood
MH  - Receptors, Aryl Hydrocarbon/agonists/metabolism
MH  - Wastewater/chemistry
EDAT- 2012/08/04 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/04 06:00
PHST- 2011/12/15 00:00 [received]
PHST- 2012/05/03 00:00 [revised]
PHST- 2012/06/30 00:00 [accepted]
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S0045-6535(12)00864-8 [pii]
AID - 10.1016/j.chemosphere.2012.06.055 [doi]
PST - ppublish
SO  - Chemosphere. 2012 Nov;89(8):919-28. doi: 10.1016/j.chemosphere.2012.06.055. Epub 
      2012 Aug 2.