PMID- 22858453
OWN - NLM
STAT- MEDLINE
DCOM- 20140501
LR  - 20130614
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 44
IP  - 1
DP  - 2013 Jul
TI  - Outcomes of HeartWare Ventricular Assist System support in 141 patients: a 
      single-centre experience.
PG  - 139-45
LID - 10.1093/ejcts/ezs263 [doi]
AB  - OBJECTIVES: A third-generation ventricular assist device, the HeartWare 
      Ventricular Assist System, has demonstrated its reliability and durability in 
      animal models and clinical experience. However, studies of a large series of 
      applications are still lacking. We evaluate the safety and efficacy of the 
      HeartWare pump in 141 patients with end-stage heart failure at a single centre. 
      METHODS: A total of 141 patients (116 men and 25 women with a mean age of 52 
      years) in New York Heart Association (NYHA) Class IV received implantation of the 
      HeartWare Ventricular Assist System between August 2009 and April 2011 at the 
      Deutsches Herzzentrum Berlin. The outcomes were measured in terms of laboratory 
      data, adverse events, NYHA functional class and survival during device support. 
      RESULTS: The HeartWare system provided an adequate haemodynamic support for 
      patients both inside and outside the hospital. NYHA class improved to I-II. Organ 
      function and pulmonary vascular resistance improved significantly. In this cohort 
      of patients, 14 patients underwent heart transplantation, one had had the device 
      explanted following myocardial recovery, one had changed to another assist 
      device, 81 were on ongoing support and 44 died. The overall actuarial survival 
      rates at 6 and 12 months were 70 and 67%, respectively, and the 3-, 6- and 
      12-month survival rates on a left ventricular assist device (LVAD) support for 
      bridge to transplantation patients were 82, 81 and 79%, respectively. Infection 
      and bleeding were the main adverse events. Four patients underwent an LVAD 
      exchange for pump thrombosis. CONCLUSIONS: The HeartWare system provides a safe 
      and effective circulatory support in a population with a wide range of body 
      surface areas, with a satisfactory actuarial survival time and an improved 
      quality of life. It can be used for univentricular or biventricular support, 
      being implanted into the pericardial space with simplified surgical techniques.
FAU - Wu, Long
AU  - Wu L
AD  - Department of Cardiovascular Surgery, Xiehe Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China. wulong72@gmail.com
FAU - Weng, Yu-Guo
AU  - Weng YG
FAU - Dong, Nian-Guo
AU  - Dong NG
FAU - Krabatsch, Thomas
AU  - Krabatsch T
FAU - Stepanenko, Alexander
AU  - Stepanenko A
FAU - Hennig, Ewald
AU  - Hennig E
FAU - Hetzer, Roland
AU  - Hetzer R
LA  - eng
PT  - Journal Article
DEP - 20120801
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
CIN - Eur J Cardiothorac Surg. 2014 Apr;45(4):766. PMID: 23925129
CIN - Eur J Cardiothorac Surg. 2014 Apr;45(4):765. PMID: 23925130
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Surgical Procedures
MH  - Child
MH  - Female
MH  - *Heart Failure/epidemiology/mortality/surgery
MH  - *Heart-Assist Devices
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Heart failure
OT  - HeartWare
OT  - Ventricular assist device
EDAT- 2012/08/04 06:00
MHDA- 2014/05/03 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - ezs263 [pii]
AID - 10.1093/ejcts/ezs263 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2013 Jul;44(1):139-45. doi: 10.1093/ejcts/ezs263. Epub 
      2012 Aug 1.