PMID- 22858596
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20120924
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 223
DP  - 2012 Oct 25
TI  - Dendritic morphology changes in neurons from the prefrontal cortex, hippocampus 
      and nucleus accumbens in rats after lesion of the thalamic reticular nucleus.
PG  - 429-38
LID - S0306-4522(12)00767-1 [pii]
LID - 10.1016/j.neuroscience.2012.07.042 [doi]
AB  - Several studies in rodents have shown that dysfunctions of the thalamic reticular 
      nucleus (TRN) result in deficits of sensory gating and attentional processes, two 
      core features of schizophrenia. TRN receives inputs from the prefrontal cortex 
      (PFC) and hippocampal formation, two structures which send excitatory projections 
      to the nucleus accumbens (NAcc) and are interconnected with the basolateral 
      amygdala (BLA). Here we determined whether (and which) changes occurred four 
      weeks after a TRN lesion in the dendritic morphology of pyramidal neurons of 
      layers 3 and 5 of the PFC, neurons of ventral and dorsal hippocampus, BLA, and 
      the medium spiny neurons of the NAcc. Dendritic morphology and characteristics 
      were measured by using Golgi-Cox procedure followed by Sholl analysis. We also 
      evaluated the effects of TRN lesion on exploratory behavior assessed by 
      hole-board test and locomotor activity induced by a novel environment. We found 
      that TRN damage induced a reduction in the exploratory behavior measured by 
      hole-board test with neuronal hypotrophy in PFC (layer 5), CA1 ventral 
      hippocampus and NAcc neurons. Taken together, these data suggest that the 
      behavioral and morphological effects of TRN lesion are, at least partially, 
      mediated by limbic subregions with possible consequences for 
      schizophrenia-related behaviors.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Torres-Garcia, M E
AU  - Torres-Garcia ME
AD  - Laboratorio de Neuropsiquiatria, Instituto de Fisiologia, Universidad Autonoma de 
      Puebla, 14 Sur 6301, CP 72570, Puebla, Mexico.
FAU - Solis, O
AU  - Solis O
FAU - Patricio, A
AU  - Patricio A
FAU - Rodriguez-Moreno, A
AU  - Rodriguez-Moreno A
FAU - Camacho-Abrego, I
AU  - Camacho-Abrego I
FAU - Limon, I D
AU  - Limon ID
FAU - Flores, G
AU  - Flores G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120731
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Animals
MH  - Dendrites/*pathology
MH  - Exploratory Behavior/physiology
MH  - Hippocampus/pathology
MH  - Male
MH  - Motor Activity/physiology
MH  - Neurons/pathology/*ultrastructure
MH  - Nucleus Accumbens/*pathology
MH  - Prefrontal Cortex/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silver Staining
MH  - Statistics, Nonparametric
MH  - Thalamic Nuclei/*injuries/*pathology
MH  - Time Factors
EDAT- 2012/08/04 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2012/07/01 00:00 [revised]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - S0306-4522(12)00767-1 [pii]
AID - 10.1016/j.neuroscience.2012.07.042 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Oct 25;223:429-38. doi: 10.1016/j.neuroscience.2012.07.042. 
      Epub 2012 Jul 31.