PMID- 22859348
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20221207
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 39
IP  - 10
DP  - 2012 Oct
TI  - Natural killer cell cytolytic function in Korean patients with adult-onset 
      Still's disease.
PG  - 2000-7
LID - 10.3899/jrheum.111500 [doi]
AB  - OBJECTIVE: To investigate natural killer (NK) cell proportions, NK cell 
      cytotoxicity, and interleukin 18 (IL-18) expression, in patients with adult-onset 
      Still's disease (AOSD). METHODS: Forty-five patients with AOSD (active = 22, 
      inactive = 23) and 32 healthy controls were included. The proportions of NK cells 
      among peripheral blood mononuclear cells were assessed by flow cytometry. IL-18 
      and IL-18-binding protein (IL-18BP) concentrations were measured by ELISA. 
      Twenty-four patients with AOSD and 18 controls were examined for cytotoxic 
      activity of NK cells by co-incubating NK cells with NK-sensitive K562 cells. The 
      association of NK cell function with clinical and laboratory measures was 
      investigated. RESULTS: The proportions of NK cells were significantly lower in 
      patients with active AOSD than in patients with inactive disease and controls. NK 
      cell cytotoxic function was significantly lower in patients with AOSD than in 
      controls. NK cell proportions and cytotoxic functions were reexamined in 11 and 6 
      patients, respectively, after treatment. Low NK cell proportion and cytotoxic 
      dysfunction were improved with clinical improvements of the patients. IL-18 and 
      IL-18BP levels were much higher in patients with active AOSD than in controls. NK 
      cell cytotoxic functions were consistently low and IL-18 and IL-18BP levels were 
      constantly high in patients with AOSD, regardless of disease activity. 
      CONCLUSION: Low NK cell proportion, defective cytotoxic function, and elevated 
      IL-18 levels may be significant features of AOSD. After resolution of the acute 
      phase, low NK cell proportion was recovered and NK cell cytolytic function was 
      restored along with clinical improvement. These findings possibly contribute to 
      immunologic abnormalities in AOSD.
FAU - Park, Jeong Ha
AU  - Park JH
AD  - Department of Rheumatology, Wonju Christian Hospital, Wonju College of Medicine, 
      Yonsei University, Wonju City, Kangwon-do, South Korea.
FAU - Kim, Hee-Sun
AU  - Kim HS
FAU - Lee, Jin Sook
AU  - Lee JS
FAU - Kim, Jin Ju
AU  - Kim JJ
FAU - Jung, Kyong-Hee
AU  - Jung KH
FAU - Park, Yong-Wook
AU  - Park YW
FAU - Yoo, Dae-Hyun
AU  - Yoo DH
LA  - eng
PT  - Journal Article
DEP - 20120801
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Cytotoxicity Tests, Immunologic
MH  - Female
MH  - Humans
MH  - Interleukin-18/metabolism
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea
MH  - Still's Disease, Adult-Onset/*immunology/metabolism
EDAT- 2012/08/04 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - jrheum.111500 [pii]
AID - 10.3899/jrheum.111500 [doi]
PST - ppublish
SO  - J Rheumatol. 2012 Oct;39(10):2000-7. doi: 10.3899/jrheum.111500. Epub 2012 Aug 1.