PMID- 2285976
OWN - NLM
STAT- MEDLINE
DCOM- 19910325
LR  - 20190705
IS  - 0009-2363 (Print)
IS  - 0009-2363 (Linking)
VI  - 38
IP  - 9
DP  - 1990 Sep
TI  - Synthesis of peptides related to immunoglobulin E (IgE) and the examination of 
      their pharmacological activity.
PG  - 2463-6
AB  - Five kinds of oligopeptides H-Asp-Ser-Asp-OH (1), H-Asp-Gly-Lys-OH (2), 
      H-Ser-Asp-Gly-Lys-OH (3), H-Asp-Ser-Asp-Gly-Lys-OH (4), and 
      H-Ala-Asp-Ser-Asp-Gly-Lys-OH (5) related to immunoglobulin E (IgE) were 
      synthesized by the conventional solution method with the objective of obtaining a 
      new type of antiallergic agent. Their pharmacological activity was examined by 
      measuring the inhibition of the production of IgE and relaxation of the smooth 
      muscle contraction of rabbit aorta. H-Ala-Asp-Ser-Asp-Gly-Lys-OH (5) displayed 
      potent inhibition against the production of IgE antibody (69.6%) and relaxation 
      against the contraction of rabbit aorta.
FAU - Noguchi, K
AU  - Noguchi K
AD  - Hitachi Chemical Co., Ltd., Ibaraki Research Laboratory, Japan.
FAU - Matsuo, K
AU  - Matsuo K
FAU - Ohta, N
AU  - Ohta N
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Peptides)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibody Formation/drug effects
MH  - Aorta/drug effects/physiology
MH  - Immunoglobulin E/*chemical synthesis/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth, Vascular/drug effects/physiology
MH  - Peptides/*chemical synthesis/pharmacology
MH  - Rabbits
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
AID - 10.1248/cpb.38.2463 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2463-6. doi: 10.1248/cpb.38.2463.