PMID- 22859933
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 7
DP  - 2012
TI  - Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism 
      and brain morphology.
PG  - e38469
LID - 10.1371/journal.pone.0038469 [doi]
LID - e38469
AB  - In this study of the effect of bipolar status and presence of BDNF Val66Met 
      polymorphism on differences in regional brain volumes, we hypothesized based on 
      previous studies that 1) bipolar subjects will have smaller regional brain 
      volumes than healthy controls; 2) BDNF Met66 allele carriers within the same 
      population are likely to have smaller regional brain volumes as compared to Val66 
      homozygyotes. In our Caucasian sample of 166 bipolar subjects and 64 
      gender-matched healthy controls, we found significant decreases in total (p = 
      0.005) and regional gray matter volumes in bipolar patients compared to healthy 
      controls, more pronounced in the inferior and posterior parts of the brain, 
      together with a concomitant increase in total CSF (p = 0.012) particularly in the 
      lateral ventricles (p = 0.023). However, there was no difference in white matter 
      volumes noted by other studies. Furthermore we did not find significant 
      differences in other brain regions that have been reported by other authors. Nor 
      did we find a significant effect of BDNF on these measurements.
FAU - Teh, Cheryl Ann
AU  - Teh CA
AD  - Neuroscience and Behavioral Disorders Program, Duke-National University of 
      Singapore Graduate School of Medicine, Singapore, Singapore.
FAU - Lee, Tih-Shih
AU  - Lee TS
FAU - Kuchibhatla, Margaratha
AU  - Kuchibhatla M
FAU - Ashley-Koch, Allison
AU  - Ashley-Koch A
FAU - Macfall, James
AU  - Macfall J
FAU - Krishnan, Ranga
AU  - Krishnan R
FAU - Beyer, John
AU  - Beyer J
LA  - eng
GR  - R01 MH057027/MH/NIMH NIH HHS/United States
GR  - U01 MH068848/MH/NIMH NIH HHS/United States
GR  - #MH68848/MH/NIMH NIH HHS/United States
GR  - #MH57027/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120730
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amino Acid Substitution
MH  - Bipolar Disorder/*genetics
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organ Size/genetics
MH  - *Polymorphism, Single Nucleotide
PMC - PMC3408450
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/08/04 06:00
MHDA- 2013/04/12 06:00
PMCR- 2012/07/30
CRDT- 2012/08/04 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2012/05/07 00:00 [accepted]
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
PHST- 2012/07/30 00:00 [pmc-release]
AID - PONE-D-11-08927 [pii]
AID - 10.1371/journal.pone.0038469 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(7):e38469. doi: 10.1371/journal.pone.0038469. Epub 2012 Jul 30.