PMID- 22859936
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 7
DP  - 2012
TI  - The -2518A/G polymorphism in the MCP-1 gene and tuberculosis risk: a 
      meta-analysis.
PG  - e38918
LID - 10.1371/journal.pone.0038918 [doi]
LID - e38918
AB  - BACKGROUND: The -2518A/G polymorphism in the monocyte chemoattractant protein-1 
      (MCP-1) gene has been implicated in the susceptibility to tuberculosis (TB), but 
      the results are not conclusive. The aim of this study is to investigate the 
      association between the -2518A/G polymorphism in the MCP-1 gene and the risk of 
      tuberculosis by meta-analysis. METHODS: We searched Pubmed, Embase, CNKI and 
      Wanfang databases, covering all studies until April 29(th), 2011. Statistical 
      analyses were performed using the Revman4.2 and STATA10.0 software. RESULTS: A 
      total of 5341 cases and 6075 controls in 13 case-control studies were included in 
      the meta-analysis. The results indicated that the GG homozygote carriers had a 
      67% increased risk of TB compared with the A allele carriers (GG vs. GA+AA: OR = 
      1.67, 95%CI = 1.25-2.23, P = 0.0006). In the subgroup analysis by ethnicity, 
      significant elevated risks were found in Asians and Latinos, but not in Africans 
      (GG vs. GA+AA: OR = 1.79, 95%CI = 1.19-2.70 and P = 0.005 for Asians; OR = 2.15, 
      95%CI = 1.32-3.51 and P = 0.002 for Latinos; OR = 1.28, 95%CI = 0.45-3.64 and P = 
      0.65 for Africans). CONCLUSION: This meta-analysis suggested that the -2518A/G 
      polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, 
      while not in Africans.
FAU - Zhang, Yonggang
AU  - Zhang Y
AD  - Department of Respiratory Medicine, West China Hospital of Sichuan University, 
      Chengdu, Sichuan, China.
FAU - Zhang, Jie
AU  - Zhang J
FAU - Zeng, Lingjun
AU  - Zeng L
FAU - Huang, Honglang
AU  - Huang H
FAU - Yang, Min
AU  - Yang M
FAU - Fu, Xiaowei
AU  - Fu X
FAU - Tian, Can
AU  - Tian C
FAU - Xiang, Zhangpeng
AU  - Xiang Z
FAU - Huang, Jin
AU  - Huang J
FAU - Fan, Hong
AU  - Fan H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20120730
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Homozygote
MH  - Humans
MH  - Models, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Risk
MH  - Sequence Analysis, DNA
MH  - Tuberculosis, Pulmonary/ethnology/*genetics
PMC - PMC3408439
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/08/04 06:00
MHDA- 2013/04/12 06:00
PMCR- 2012/07/30
CRDT- 2012/08/04 06:00
PHST- 2011/07/20 00:00 [received]
PHST- 2012/05/15 00:00 [accepted]
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
PHST- 2012/07/30 00:00 [pmc-release]
AID - PONE-D-11-08927 [pii]
AID - 10.1371/journal.pone.0038918 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(7):e38918. doi: 10.1371/journal.pone.0038918. Epub 2012 Jul 30.