PMID- 22860462
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20120806
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 37
IP  - 10
DP  - 2012 May
TI  - [Effect of Lycium ruthenicum anthocyanins on atherosclerosis in mice].
PG  - 1460-6
AB  - OBJECTIVE: To study the effect of Lycium ruthenicum anthocyanins on 
      atherosclerosis (AS) in mice. METHOD: Normal mice were taken as the control 
      group, and hyperlipemia mice were divided into the model group, Lycium ruthenicum 
      anthocyanins low, medium and high dose groups, and the simvastatin drug control 
      group. After the oral administration, blood lipid indicators were detected by 
      enzymatic analysis. The histomorphological changes in aortas, hearts and livers 
      were observed, and liver-related indicators were determined by using 
      hematoxylin-eosin (HE) staining. RESULT: Compared with the high-fat group, L. 
      ruthenicum anthocyanins low, medium and high dose groups showed significant 
      decrease in total cholesterol (TC), triglyceride (TG), low-density lipoprotein 
      cholesterol (LDL-C) and atherosclerotic index (AI) (P < 0.05). However, 
      high-density lipoprotein cholesterol (HDL-C) level showed a trend of higher than 
      the model group. Liver's total antioxidant capacity (T-AOC), Glutathione 
      peroxidase (GSH-PX), lipoprotein lipase (LPL) were significantly increased (P < 
      0.05), malondialdehyde (MDA) was markedly decreased (P < 0.01); the percentage of 
      aortic plaque area of each anthocyanins dose group in the total area was 
      significantly lower than the model group (P < 0.05); severity of aorta, heart and 
      liver were significantly lighter than the high-fat group. But the media dose 
      group was similar with the simvastatin group. CONCLUSION: L. ruthenicum 
      anthocyanins can interfere the formation of AS, while lowering blood lipid levels 
      in mice.
FAU - Lin, Li
AU  - Lin L
AD  - Life Sciences Institute, Xinjiang Normal University, Urumqi 830054, China. 
      linli0426@126.com
FAU - Li, Jin
AU  - Li J
FAU - Lv, Haiying
AU  - Lv H
FAU - Ma, Yuting
AU  - Ma Y
FAU - Qian, Yiping
AU  - Qian Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Anthocyanins)
RN  - 0 (Lipids)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
SB  - IM
MH  - Animals
MH  - Anthocyanins/*therapeutic use
MH  - Atherosclerosis/*prevention & control
MH  - Body Weight/drug effects
MH  - Glutathione Peroxidase/metabolism
MH  - Hypercholesterolemia/blood/*drug therapy/pathology
MH  - Lipids/blood
MH  - Liver/pathology
MH  - Lycium/*chemistry
MH  - Male
MH  - Mice
MH  - Phytotherapy
EDAT- 2012/08/07 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2012 May;37(10):1460-6.