PMID- 22862420
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20121002
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 123
IP  - 2
DP  - 2012 Oct
TI  - Matrix metalloproteinase-3 in the central nervous system: a look on the bright 
      side.
PG  - 203-16
LID - 10.1111/j.1471-4159.2012.07900.x [doi]
AB  - Matrix metalloproteinases (MMPs) are a large family of proteases involved in many 
      cell-matrix and cell-cell signalling processes through activation, inactivation 
      or release of extracellular matrix (ECM) and non-ECM molecules, such as growth 
      factors and receptors. Uncontrolled MMP activities underlie the pathophysiology 
      of many disorders. Also matrix metalloproteinase-3 (MMP-3) or stromelysin-1 
      contributes to several pathologies, such as cancer, asthma and rheumatoid 
      arthritis, and has also been associated with neurodegenerative diseases like 
      Alzheimer's disease, Parkinson's disease and multiple sclerosis. However, based 
      on defined MMP spatiotemporal expression patterns, the identification of novel 
      candidate molecular targets and in vitro and in vivo studies, a beneficial role 
      for MMPs in CNS physiology and recovery is emerging. The main purpose of this 
      review is to shed light on the recently identified roles of MMP-3 in normal brain 
      development and in plasticity and regeneration after CNS injury and disease. As 
      such, MMP-3 is correlated with neuronal migration and neurite outgrowth and 
      guidance in the developing CNS and contributes to synaptic plasticity and 
      learning in the adult CNS. Moreover, a strict spatiotemporal MMP-3 up-regulation 
      in the injured or diseased CNS might support remyelination and neuroprotection, 
      as well as genesis and migration of stem cells in the damaged brain.
CI  - (c) 2012 The Authors Journal of Neurochemistry (c) 2012 International Society for 
      Neurochemistry.
FAU - Van Hove, Inge
AU  - Van Hove I
AD  - Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and 
      Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium.
FAU - Lemmens, Kim
AU  - Lemmens K
FAU - Van de Velde, Sarah
AU  - Van de Velde S
FAU - Verslegers, Mieke
AU  - Verslegers M
FAU - Moons, Lieve
AU  - Moons L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120903
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Cell Movement/physiology
MH  - Central Nervous System Diseases/*enzymology/pathology
MH  - Humans
MH  - Matrix Metalloproteinase 3/*physiology
MH  - Nerve Regeneration/physiology
MH  - Neuronal Plasticity/physiology
MH  - Synaptic Potentials/physiology
EDAT- 2012/08/07 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/05/16 00:00 [received]
PHST- 2012/07/11 00:00 [revised]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1111/j.1471-4159.2012.07900.x [doi]
PST - ppublish
SO  - J Neurochem. 2012 Oct;123(2):203-16. doi: 10.1111/j.1471-4159.2012.07900.x. Epub 
      2012 Sep 3.