PMID- 22863291
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20220408
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 321
IP  - 1-2
DP  - 2012 Oct 15
TI  - Serum neurofilament concentrations in children with prolonged febrile seizures.
PG  - 39-42
LID - 10.1016/j.jns.2012.07.043 [doi]
AB  - OBJECTIVE: Neurofilament (NF) is a major cytoskeletal protein of neurons. 
      Elevation of serum NF concentration suggests neuronal injury, especially damage 
      to axons. We assessed neuronal damage in febrile seizure (FS) by using NF. 
      METHODS: We used enzyme-linked immunosorbent assay to measure serum levels of the 
      phosphorylated form of NF-heavy chain (pNF-H) in 42 children with FS and 28 
      controls. RESULTS: Serum pNF-H levels in children with prolonged febrile seizure 
      (PFS) (n=29) were significantly higher than those in the controls (p<0.001). 
      There were no significant differences in serum pNF-H levels between children with 
      simple febrile seizure (n=9) and the controls. There was a significant 
      correlation between seizure duration and serum pNF-H levels during the first week 
      in children with FS (p=0.022, r=0.37). CONCLUSION: Our results suggest that PFS 
      could lead to some degree of neuronal damage even in the absence of abnormal 
      clinical neurological findings during the short-term follow up period.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Matsushige, Takeshi
AU  - Matsushige T
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 
      Yamaguchi, Japan. matsu@yamaguchi-u.ac.jp
FAU - Inoue, Hirofumi
AU  - Inoue H
FAU - Fukunaga, Shinnosuke
AU  - Fukunaga S
FAU - Hasegawa, Shunji
AU  - Hasegawa S
FAU - Okuda, Masayuki
AU  - Okuda M
FAU - Ichiyama, Takashi
AU  - Ichiyama T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120803
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Neurofilament Proteins)
RN  - 108688-71-7 (neurofilament protein H)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neurofilament Proteins/*blood
MH  - Seizures, Febrile/*blood
EDAT- 2012/08/07 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/07/16 00:00 [revised]
PHST- 2012/07/18 00:00 [accepted]
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - S0022-510X(12)00396-6 [pii]
AID - 10.1016/j.jns.2012.07.043 [doi]
PST - ppublish
SO  - J Neurol Sci. 2012 Oct 15;321(1-2):39-42. doi: 10.1016/j.jns.2012.07.043. Epub 
      2012 Aug 3.