PMID- 22863808
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20161125
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 435-436
DP  - 2012 Oct 1
TI  - Circulating metals and persistent organic pollutant concentrations in Canadian 
      and non-Canadian born primiparous women from five Canadian centres: results of a 
      pilot biomonitoring study.
PG  - 326-36
LID - 10.1016/j.scitotenv.2012.06.070 [doi]
AB  - The developing foetus is thought to be at increased risk from exposure to 
      environmental contaminants; however, developmental exposure data is notably 
      lacking for many contaminants. Moreover, potential regional differences or effect 
      of place of birth on residue levels measured in pregnant women is also unknown. 
      Therefore, as part of a multinational biomonitoring study, 125 primiparous 
      pregnant Canadian women were recruited from five Canadian centres (Vancouver, 
      Calgary, Hamilton, Ottawa, and Halifax). Metals in whole blood and persistent 
      organic pollutants (POPs) in plasma were measured by inductively coupled plasma 
      mass spectrometry (ICPMS) and gas chromatography-mass spectrometry (GCMS), 
      respectively. Of the 125 women recruited to this study, complete data sets were 
      available for 123 of which 103 were Canadian born. Data were analysed by analysis 
      of covariance and linear mixed models using age and body mass index as 
      covariates. The metals cadmium (Cd), cobalt (Co), lead (Pb), nickel (Ni), 
      selenium (Se), and total mercury (Hg) were detected in more than 93% of the 
      samples tested. beta-Hexachlorohexane (beta-HCH), oxychlordane, trans-nonachlor, 
      1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), polybrominated diphenyl 
      ether (PBDE) congeners (PBDE-153, PBDE-47), polychlorinated biphenyl (PCB) 
      congeners (PCB-138, -153, and -180), and the dioxin-like PCB congener PCB-118 
      were quantified in greater than 70% of the samples tested. Significant 
      differences in the concentrations of Cd, Ni, PCB-153, and p,p'-DDE were found 
      between the centres studied. Furthermore, foreign-born pregnant women had 
      significantly higher concentrations of Cd, beta-HCH, PBDE-47, PCB-138, -153, -180, 
      and p,p'-DDE compared to Canadian born pregnant women. Taken together, the data 
      suggest that there are potential regional differences in contaminant body burden 
      and place of birth may also contribute to differences in maternal residue 
      concentrations.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Foster, Warren G
AU  - Foster WG
AD  - Department of Obstetrics & Gynecology, McMaster University, Hamilton, Ontario, 
      Canada. fosterw@mcmaster.ca
FAU - Cheung, Anthony P
AU  - Cheung AP
FAU - Davis, Karelyn
AU  - Davis K
FAU - Graves, Gillian
AU  - Graves G
FAU - Jarrell, John
AU  - Jarrell J
FAU - Leblanc, Alain
AU  - Leblanc A
FAU - Liang, Chun Lei
AU  - Liang CL
FAU - Leech, Tara
AU  - Leech T
FAU - Walker, Mark
AU  - Walker M
FAU - Weber, Jean Philippe
AU  - Weber JP
FAU - Van Oostdam, Jay
AU  - Van Oostdam J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120803
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Metals, Heavy)
RN  - 12789-03-6 (Chlordan)
RN  - 27304-13-8 (oxychlordane)
RN  - 7REL09ZX35 (pentabromodiphenyl ether)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Canada
MH  - Chlordan/analogs & derivatives/blood
MH  - Environmental Monitoring
MH  - Environmental Pollutants/blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Metals, Heavy/*blood
MH  - Pilot Projects
MH  - Pregnancy
MH  - Young Adult
EDAT- 2012/08/07 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/02/11 00:00 [received]
PHST- 2012/06/22 00:00 [revised]
PHST- 2012/06/22 00:00 [accepted]
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - S0048-9697(12)00903-5 [pii]
AID - 10.1016/j.scitotenv.2012.06.070 [doi]
PST - ppublish
SO  - Sci Total Environ. 2012 Oct 1;435-436:326-36. doi: 
      10.1016/j.scitotenv.2012.06.070. Epub 2012 Aug 3.