PMID- 22864134
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 51
IP  - 15
DP  - 2012
TI  - Sitagliptin (DPP-4 inhibitor)-induced rheumatoid arthritis in type 2 diabetes 
      mellitus: a case report.
PG  - 2041-4
AB  - A dipeptidyl peptidase (DPP)-4 inhibitor, commonly used to treat patients with 
      type 2 diabetes, has caused concern because of immune system side effects. We 
      report a 48-year-old woman with type 2 diabetes who was diagnosed with rheumatoid 
      arthritis (RA) after continued polyarthritis and an increase in rheumatoid factor 
      up to 86 IU/mL after three months of treatment with sitagliptin, a DPP-4 
      inhibitor. The shared epitope (SE)-containing human leukocyte antigen (HLA)-DRB1 
      alleles, which are important predisposing factors for RA, were positive. RA might 
      have been triggered by sitagliptin due to a predisposing condition.
FAU - Yokota, Kazuki
AU  - Yokota K
AD  - Kobe University Graduate School of Medicine, Japan. yoyochibiakiko@yahoo.co.jp
FAU - Igaki, Naoya
AU  - Igaki N
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120801
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Dipeptidyl-Peptidase IV Inhibitors)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Pyrazines)
RN  - 0 (Triazoles)
RN  - 9009-79-4 (Rheumatoid Factor)
RN  - TS63EW8X6F (Sitagliptin Phosphate)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/*etiology/genetics/immunology
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Dipeptidyl-Peptidase IV Inhibitors/adverse effects
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/genetics/immunology
MH  - Humans
MH  - Middle Aged
MH  - Pyrazines/*adverse effects
MH  - Rheumatoid Factor/blood
MH  - Sitagliptin Phosphate
MH  - Triazoles/*adverse effects
EDAT- 2012/08/07 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - DN/JST.JSTAGE/internalmedicine/51.7592 [pii]
AID - 10.2169/internalmedicine.51.7592 [doi]
PST - ppublish
SO  - Intern Med. 2012;51(15):2041-4. doi: 10.2169/internalmedicine.51.7592. Epub 2012 
      Aug 1.