PMID- 22864999
OWN - NLM
STAT- MEDLINE
DCOM- 20130624
LR  - 20211021
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 35
IP  - 6
DP  - 2012 Dec
TI  - Inhibitory effects of panduratin A on allergy-related mediator production in rat 
      basophilic leukemia mast cells.
PG  - 1904-15
LID - 10.1007/s10753-012-9513-y [doi]
AB  - Immediate-type hypersensitivity is characterized by elevated levels of 
      immunoglobulin E (IgE) and activated mast cell plays a crucial role by releasing 
      granule contents, lipid-derived mediators, cytokines, and chemokines. To evaluate 
      the antiallergic effects of panduratin A isolated from Boesenbergia pandurata 
      Roxb., we determined its effects on calcium (Ca(2+)) influx, degranulation, and 
      inflammatory mediators in calcium ionophore A23187 and phorbol 12-myristate 
      13-acetate (PMA)-stimulated rat basophilic leukemia (RBL-2H3) cells. Panduratin A 
      (20 muM) inhibited secretion of beta-hexosaminidase (46.69 +/- 9.6 %), histamine 
      (34.32 +/- 2.1 %), and Ca(2+) influx (43.84 %). Panduratin A reduced the production 
      of prostaglandin E(2) (PGE(2), 47.58 +/- 3.4 %), leukotriene B(4) (LTB(4), 
      98.15 +/- 1.6 %), and the mRNA expression of cyclooxygenase-2, 5-lipoxygenase, 
      interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha. Furthermore, panduarin A 
      attenuated phosphorylation of Akt, the mitogen-activated protein kinases (MAPK) 
      extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase 
      (JNK) expression. These results indicate that panduratin A might be useful as an 
      agent against immediate-type hypersensitivity.
FAU - Choi, Yuri
AU  - Choi Y
AD  - Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 
      120-749, South Korea.
FAU - Kim, Myung Suk
AU  - Kim MS
FAU - Hwang, Jae-Kwan
AU  - Hwang JK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Chalcones)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-13)
RN  - 0 (Plant Extracts)
RN  - 0 (Prostaglandins E)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 207137-56-2 (Interleukin-4)
RN  - 27N2BIM2CR (panduratin A)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 820484N8I3 (Histamine)
RN  - EC 1.13.11.34 (Arachidonate 5-Lipoxygenase)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Arachidonate 5-Lipoxygenase/genetics
MH  - Calcimycin/pharmacology
MH  - Calcium/metabolism
MH  - Cell Degranulation/drug effects/immunology
MH  - Cell Line, Tumor
MH  - Chalcones/*pharmacology
MH  - Cyclooxygenase 2/genetics
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Histamine/metabolism
MH  - Histamine Release/*drug effects/immunology
MH  - Hypersensitivity, Immediate/*drug therapy
MH  - Immunoglobulin E/immunology
MH  - Inflammation Mediators
MH  - Interleukin-13/genetics
MH  - Interleukin-4/genetics
MH  - JNK Mitogen-Activated Protein Kinases/metabolism
MH  - Leukemia, Basophilic, Acute/*drug therapy
MH  - Leukotriene B4/biosynthesis
MH  - *Mast Cells/drug effects/immunology/metabolism
MH  - Phosphorylation
MH  - Plant Extracts/pharmacology
MH  - Prostaglandins E/biosynthesis
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Signal Transduction/immunology
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - Zingiberaceae/metabolism
MH  - beta-N-Acetylhexosaminidases/*drug effects/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2012/08/07 06:00
MHDA- 2013/06/26 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - 10.1007/s10753-012-9513-y [doi]
PST - ppublish
SO  - Inflammation. 2012 Dec;35(6):1904-15. doi: 10.1007/s10753-012-9513-y.