PMID- 22867780 OWN - NLM STAT- MEDLINE DCOM- 20121015 LR - 20220409 IS - 1524-4733 (Electronic) IS - 1098-3015 (Linking) VI - 15 IP - 5 DP - 2012 Jul-Aug TI - Interim scoring for the EQ-5D-5L: mapping the EQ-5D-5L to EQ-5D-3L value sets. PG - 708-15 LID - 10.1016/j.jval.2012.02.008 [doi] AB - BACKGROUND: A five-level version of the EuroQol five-dimensional (EQ-5D) descriptive system (EQ-5D-5L) has been developed, but value sets based on preferences directly elicited from representative general population samples are not yet available. The objective of this study was to develop values sets for the EQ-5D-5L by means of a mapping ("crosswalk") approach to the currently available three-level version of the EQ-5D (EQ-5D-3L) values sets. METHODS: The EQ-5D-3L and EQ-5D-5L descriptive systems were coadministered to respondents with conditions of varying severity to ensure a broad range of levels of health across EQ-5D questionnaire dimensions. We explored four models to generate value sets for the EQ-5D-5L: linear regression, nonparametric statistics, ordered logistic regression, and item-response theory. Criteria for the preferred model included theoretical background, statistical fit, predictive power, and parsimony. RESULTS: A total of 3691 respondents were included. All models had similar fit statistics. Predictive power was slightly better for the nonparametric and ordered logistic regression models. In considering all criteria, the nonparametric model was selected as most suitable for generating values for the EQ-5D-5L. CONCLUSIONS: The nonparametric model was preferred for its simplicity while performing similarly to the other models. Being independent of the value set that is used, it can be applied to transform any EQ-5D-3L value set into EQ-5D-5L index values. Strengths of this approach include compatibility with three-level value sets. A limitation of any crosswalk is that the range of index values is restricted to the range of the EQ-5D-3L value sets. CI - Copyright (c) 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved. FAU - van Hout, Ben AU - van Hout B AD - University of Sheffield, Sheffield, UK. FAU - Janssen, M F AU - Janssen MF FAU - Feng, You-Shan AU - Feng YS FAU - Kohlmann, Thomas AU - Kohlmann T FAU - Busschbach, Jan AU - Busschbach J FAU - Golicki, Dominik AU - Golicki D FAU - Lloyd, Andrew AU - Lloyd A FAU - Scalone, Luciana AU - Scalone L FAU - Kind, Paul AU - Kind P FAU - Pickard, A Simon AU - Pickard AS LA - eng GR - PRP 070-0065/Department of Health/United Kingdom PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120524 PL - United States TA - Value Health JT - Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research JID - 100883818 SB - IM MH - Adult MH - Aged MH - *Decision Making MH - Female MH - Humans MH - Linear Models MH - Logistic Models MH - Male MH - Middle Aged MH - *Models, Statistical MH - *Quality of Life MH - Statistics, Nonparametric MH - *Surveys and Questionnaires EDAT- 2012/08/08 06:00 MHDA- 2012/10/16 06:00 CRDT- 2012/08/08 06:00 PHST- 2011/08/17 00:00 [received] PHST- 2012/01/11 00:00 [revised] PHST- 2012/02/19 00:00 [accepted] PHST- 2012/08/08 06:00 [entrez] PHST- 2012/08/08 06:00 [pubmed] PHST- 2012/10/16 06:00 [medline] AID - S1098-3015(12)00058-7 [pii] AID - 10.1016/j.jval.2012.02.008 [doi] PST - ppublish SO - Value Health. 2012 Jul-Aug;15(5):708-15. doi: 10.1016/j.jval.2012.02.008. Epub 2012 May 24.