PMID- 22867973
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20191210
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 223
DP  - 2012 Oct 25
TI  - Negative effects of ultrafine particle exposure during forced exercise on the 
      expression of Brain-Derived Neurotrophic Factor in the hippocampus of rats.
PG  - 131-9
LID - S0306-4522(12)00805-6 [pii]
LID - 10.1016/j.neuroscience.2012.07.057 [doi]
AB  - Exercise improves cognitive function, and Brain-Derived Neurotrophic Factor 
      (BDNF) plays a key role in this process. We recently reported that particulate 
      matter (PM) exposure negatively contributed to the exercise-induced increase in 
      human serum BDNF concentration. Furthermore, PM exposure is associated with 
      neuroinflammation and cognitive decline. The aim of this study was to investigate 
      the effect of exposure to ultrafine particles (UFP) during a single bout of 
      forced exercise on the expression of inflammatory (IL1alpha, IL1beta, TNF, IL6, NOS2, 
      NOS3) and oxidative stress (NFE2L2)-related genes, as well as BDNF in the brain 
      of rats. Four groups (n=6/group) of Wistar rats were exposed for 90 min to one of 
      the following exposure regimes: UFP+exercise, UFP+rest, ambient air+exercise, 
      ambient air+rest (control). Hippocampus, olfactory bulb and prefrontal cortex 
      were collected 24h after exposure. Gene expression changes were analyzed with 
      real-time PCR. In the condition ambient air+exercise, hippocampal expression of 
      BDNF and NFE2L2 was up-regulated, while the expression of IL1alpha and NOS3 in the 
      prefrontal cortex and IL1alpha in the olfactory bulb was down-regulated compared to 
      the control. In contrast, gene expression in the condition UFP+exercise did not 
      differ from the control. In the condition UFP+rest, hippocampal expression of 
      NFE2L2 was down-regulated and there was a trend toward down-regulation of BDNF 
      expression compared to the control. This study shows a negative effect of UFP 
      exposure on the exercise-induced up-regulation of BDNF gene expression in the 
      hippocampus of rats.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Bos, I
AU  - Bos I
AD  - Environmental Risk and Health, Flemish Institute for Technological Research 
      (VITO), Mol, Belgium. inge.bos@vito.be
FAU - De Boever, P
AU  - De Boever P
FAU - Int Panis, L
AU  - Int Panis L
FAU - Sarre, S
AU  - Sarre S
FAU - Meeusen, R
AU  - Meeusen R
LA  - eng
PT  - Journal Article
DEP - 20120804
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Particulate Matter)
RN  - 0 (RNA, Messenger)
RN  - 0 (Silicones)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cytokines/genetics/metabolism
MH  - Gene Expression Regulation/*drug effects/physiology
MH  - Hippocampus/*drug effects/*metabolism
MH  - Male
MH  - Nitric Oxide Synthase Type I/genetics/metabolism
MH  - Nitric Oxide Synthase Type II/genetics/metabolism
MH  - Particulate Matter
MH  - *Physical Conditioning, Animal
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Silicones/*pharmacology
EDAT- 2012/08/08 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/07/24 00:00 [revised]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - S0306-4522(12)00805-6 [pii]
AID - 10.1016/j.neuroscience.2012.07.057 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Oct 25;223:131-9. doi: 10.1016/j.neuroscience.2012.07.057. 
      Epub 2012 Aug 4.