PMID- 22867997
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20220331
IS  - 2210-7762 (Print)
VI  - 205
IP  - 7-8
DP  - 2012 Jul-Aug
TI  - A cytogenetic study of 397 consecutive acute myeloid leukemia cases identified 
      three with a t(7;21) associated with 5q abnormalities and exhibiting similar 
      clinical and biological features, suggesting a new, rare acute myeloid leukemia 
      entity.
PG  - 365-72
LID - 10.1016/j.cancergen.2012.04.007 [doi]
AB  - The RUNX1 gene is implicated in numerous chromosomal translocations that occur in 
      acute myeloid leukemia (AML) and result in chimeric genes. In this study, 397 
      consecutive AML cases were analyzed using RUNX1 fluorescence in situ 
      hybridization (FISH) probes. Three cases of the recently described translocation, 
      t(7;21)(p22;q22), were identified, which expressed RUNX1-USP42 
      (ubiquitin-specific protease 42) fusion transcripts, associated with 5q 
      abnormalities and hyperploidy. These cases displayed homogeneous morphological 
      features (including phagocytosis) and aberrantly expressed CD56 and CD7 lymphoid 
      antigens. Although very few data are available from previously reported cases, 
      when these features are present, a detailed chromosomal analysis, including 
      hybridization with RUNX1 FISH probes, should be performed at diagnosis to 
      recognize chromosomal abnormalities. Additional cases of t(7;21) positive AML 
      should be evaluated to characterize this potentially rare AML entity in greater 
      detail.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Jeandidier, Eric
AU  - Jeandidier E
AD  - Genetics Department, Centre Hospitalier de Mulhouse, Mulhouse, France.
FAU - Gervais, Carine
AU  - Gervais C
FAU - Radford-Weiss, Isabelle
AU  - Radford-Weiss I
FAU - Zink, Estelle
AU  - Zink E
FAU - Gangneux, Catherine
AU  - Gangneux C
FAU - Eischen, Alice
AU  - Eischen A
FAU - Galoisy, Anne Cecile
AU  - Galoisy AC
FAU - Helias, Catherine
AU  - Helias C
FAU - Dano, Laurent
AU  - Dano L
FAU - Cammarata, Ornella
AU  - Cammarata O
FAU - Jung, Georges
AU  - Jung G
FAU - Harzallah, Ines
AU  - Harzallah I
FAU - Guerin, Eric
AU  - Guerin E
FAU - Martzolff, Lionel
AU  - Martzolff L
FAU - Drenou, Bernard
AU  - Drenou B
FAU - Lioure, Bruno
AU  - Lioure B
FAU - Tancredi, Celine
AU  - Tancredi C
FAU - Rimelen, Valerie
AU  - Rimelen V
FAU - Mauvieux, Laurent
AU  - Mauvieux L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
SB  - IM
MH  - Adult
MH  - *Chromosomes, Human, Pair 21
MH  - *Chromosomes, Human, Pair 5
MH  - *Chromosomes, Human, Pair 7
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 2012/08/08 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/06/04 00:00 [received]
PHST- 2012/04/10 00:00 [revised]
PHST- 2012/04/14 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S2210-7762(12)00121-4 [pii]
AID - 10.1016/j.cancergen.2012.04.007 [doi]
PST - ppublish
SO  - Cancer Genet. 2012 Jul-Aug;205(7-8):365-72. doi: 10.1016/j.cancergen.2012.04.007.