PMID- 22868001
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20120807
IS  - 2210-7762 (Print)
VI  - 205
IP  - 7-8
DP  - 2012 Jul-Aug
TI  - When are apparently non-clonal abnormalities in bone marrow chromosome studies 
      actually clonal?
PG  - 405-9
LID - 10.1016/j.cancergen.2012.04.003 [doi]
AB  - The observation of an apparently non-clonal abnormal cell in a cytogenetic study 
      for a hematologic neoplasm opens the possibility of a small, or slowly 
      proliferating, abnormal clone. Many laboratories analyze additional cells or 
      reflex to fluorescence in situ hybridization (FISH) to evaluate this possibility 
      further. In a retrospective study of 500 cases with a non-clonal abnormal cell 
      identified in a 20-cell analysis, we found that the benefit of additional 
      metaphase analysis was limited to specific categories of abnormal karyotypes, 
      including those with a complex karyotype or a classic abnormality known to be a 
      recurring finding in hematologic neoplasms, and excluding all other categories.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hutchens, Chandra
AU  - Hutchens C
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
FAU - Ketterling, Rhett P
AU  - Ketterling RP
FAU - Van Dyke, Daniel L
AU  - Van Dyke DL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
SB  - IM
MH  - Bone Marrow/*ultrastructure
MH  - *Chromosomes, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Retrospective Studies
EDAT- 2012/08/08 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/10/24 00:00 [received]
PHST- 2012/03/09 00:00 [revised]
PHST- 2012/04/06 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S2210-7762(12)00106-8 [pii]
AID - 10.1016/j.cancergen.2012.04.003 [doi]
PST - ppublish
SO  - Cancer Genet. 2012 Jul-Aug;205(7-8):405-9. doi: 10.1016/j.cancergen.2012.04.003.