PMID- 22868196
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20161125
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 89
IP  - 8
DP  - 2012 Nov
TI  - Partitioning of persistent organic pollutants (POPs) between human serum and 
      breast milk: a literature review.
PG  - 911-8
LID - 10.1016/j.chemosphere.2012.06.049 [doi]
AB  - The literature was reviewed to assess the relationship between the lipid adjusted 
      concentration in human serum and breast milk (expressed as the serum/milk ratio) 
      of a broad range of POPs in paired samples. Thirteen studies were identified, 
      including seven studies that reported serum/milk ratios for polychlorinated 
      dibenzo-dioxins and -furans (PCDD/Fs), ten for polychlorinated biphenyls (PCBs), 
      five for polybrominated diphenyl ethers (PBDEs), and five for organochlorine 
      pesticides (OCPs). Mean serum/milk ratios ranged between 0.7 and 25 depending on 
      the compound and congener. For PCDD/Fs, PCBs and PBDEs, a clear trend of 
      increasing mean serum/milk ratio by increasing molar volume, hydrophobicity and 
      number of halogen substitutes was observed. The mean serum/milk ratios reported 
      by the 13 studies summarized here will aid comparison between human POPs exposure 
      studies using either serum or milk samples. More studies are needed to allow a 
      valid comparison between data obtained from analysis of breast milk and serum 
      samples for a broader range of POPs. Furthermore such studies may shed light on 
      compound specific factors as well as other determinants that may affect the 
      partitioning and partition kinetics of POPs between serum and breast milk.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Mannetje, Andrea 't
AU  - Mannetje A'
AD  - Centre for Public Health Research, Massey University, Wellington, New Zealand. 
      a.mannetje@massey.ac.nz
FAU - Coakley, Jonathan
AU  - Coakley J
FAU - Mueller, Jochen F
AU  - Mueller JF
FAU - Harden, Fiona
AU  - Harden F
FAU - Toms, Leisa-Maree
AU  - Toms LM
FAU - Douwes, Jeroen
AU  - Douwes J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120804
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Benzofurans)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Polymers)
RN  - 0 (polychlorodibenzofuran)
RN  - 7REL09ZX35 (pentabromodiphenyl ether)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Benzofurans/analysis/blood
MH  - Environmental Pollutants/*analysis/blood
MH  - Halogenated Diphenyl Ethers/analysis/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/blood
MH  - Milk/*chemistry
MH  - Organic Chemicals/*analysis/blood
MH  - Pesticides/analysis/blood
MH  - Polychlorinated Biphenyls/analysis/blood
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/analysis/blood
MH  - Polymers/analysis
EDAT- 2012/08/08 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/06/23 00:00 [received]
PHST- 2012/05/24 00:00 [revised]
PHST- 2012/06/30 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S0045-6535(12)00858-2 [pii]
AID - 10.1016/j.chemosphere.2012.06.049 [doi]
PST - ppublish
SO  - Chemosphere. 2012 Nov;89(8):911-8. doi: 10.1016/j.chemosphere.2012.06.049. Epub 
      2012 Aug 4.