PMID- 22868506
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20120807
IS  - 1423-0240 (Electronic)
IS  - 0378-584X (Linking)
VI  - 35
IP  - 5
DP  - 2012
TI  - Human leukocyte antigen (HLA)-DRB1*14 is associated with a high incidence of 
      acute lymphocytic leukemia.
PG  - 268-71
LID - 10.1159/000338480 [doi]
AB  - BACKGROUND: Genetic background and environmental factors play an interactive role 
      in the development of acute lymphocytic leukemia (ALL), and the human leukocyte 
      antigen (HLA) system was noted as an important genetic factor in ALL. MATERIAL 
      AND METHODS: Due to the high diversity of HLA alleles, our present study assessed 
      the possibility of an association of HLA molecules in ALL patients living in 
      Jiangsu Province, Eastern China. HLAA, -B, and -DRB1 allele distributions in 156 
      ALL patients (aged 3-54 years) were analyzed and compared with unrelated healthy 
      hematopoietic stem cell donors from the same ethnic and geographic background. 
      RESULTS: No significance was found at HLA-A, -B loci between the ALL group and 
      the control group. However, a significant difference was discovered at 
      HLA-DRB1*14 (8.65% in the ALL group versus 4.8% in the control group, pC < 0.05), 
      with an odds ratio of 1.87 (95% confidence interval 1.26- 2.80). CONCLUSION: 
      HLA-DRB1*14 may be associated with susceptibility to ALL acquisition among the 
      Jiangsu Han population.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Zhou, Min
AU  - Zhou M
AD  - Department of Hematology and Oncology, Changzhou No. 2 People's Hospital 
      Affiliated with Nanjing Medical University, Changzhou, P.R. China.
FAU - Qiu, Hairong
AU  - Qiu H
FAU - Chen, Tao
AU  - Chen T
FAU - Xiao, Rong
AU  - Xiao R
FAU - Yang, Jianhe
AU  - Yang J
FAU - Cen, Ling
AU  - Cen L
FAU - Li, Jianyong
AU  - Li J
FAU - Miao, Kourong
AU  - Miao K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120424
PL  - Switzerland
TA  - Onkologie
JT  - Onkologie
JID - 7808556
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Female
MH  - Genetic Markers/*genetics
MH  - Genetic Predisposition to Disease/*epidemiology/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*epidemiology/*genetics
MH  - Risk Assessment
MH  - Young Adult
EDAT- 2012/08/08 06:00
MHDA- 2013/01/16 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
AID - 000338480 [pii]
AID - 10.1159/000338480 [doi]
PST - ppublish
SO  - Onkologie. 2012;35(5):268-71. doi: 10.1159/000338480. Epub 2012 Apr 24.