PMID- 22868806
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20161018
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 50
IP  - 8
DP  - 2012 Feb 1
TI  - Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients 
      with sepsis treated in an intensive care unit: a preliminary report.
PG  - 1409-15
LID - /j/cclm.2012.50.issue-8/cclm-2011-0896/cclm-2011-0896.xml [pii]
LID - 10.1515/cclm-2011-0896 [doi]
AB  - BACKGROUND: There is considerable interest in the research of molecules 
      modulating the acute inflammatory response in patients with sepsis. Paraoxonases 
      (PON) are antioxidant and anti-inflammatory enzymes that inhibit the production 
      of the monocyte chemoattractant protein-1 (MCP-1). This preliminary study 
      investigated changes in PON status and MCP-1 concentrations in critically ill 
      patients with severe sepsis treated in an ICU and their relationship with the 
      evolution of disease. METHODS: This was a longitudinal, prospective and 
      observational study on 15 patients with sepsis, studied at baseline and on days 
      1, 2, 5, 7 and 10 of their stay in the ICU. In all the patients we measured serum 
      PON1 and PON3 concentrations, PON1 paraoxonase and lactonase activities, serum 
      MCP-1 concentrations, and several standard biochemical and haematological 
      parameters. RESULTS: MCP-1 concentration significantly decreased with the 
      resolution of sepsis, and this decrease was especially important during the first 
      5 days of hospitalisation. PON1 and PON3 tended to decrease during the first 5 
      days in ICU and significantly increased in days 7 and 10. Linear regression 
      analysis showed significant and direct correlations among serum MCP-1 
      concentration and lactate levels at baseline. At the end of stay, PON1 
      paraoxonase and lactonase activities were significantly correlated with organ 
      system function measurements. CONCLUSIONS: We observed an inverse pattern between 
      changes in MCP-1, and PON1 and PON3 levels in patients with sepsis, this was 
      related to the resolution of their infection after receiving treatment in an ICU.
FAU - Sans, Teresa
AU  - Sans T
AD  - Laboratori d'Analisis Cliniques, Hospital Verge de la Cinta, Institut 
      d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tortosa, 
      Spain.
FAU - Rull, Anna
AU  - Rull A
FAU - Luna, Jose
AU  - Luna J
FAU - Mackness, Bharti
AU  - Mackness B
FAU - Mackness, Michael
AU  - Mackness M
FAU - Joven, Jorge
AU  - Joven J
FAU - Ibanez, Marcos
AU  - Ibanez M
FAU - Pariente, Rainer
AU  - Pariente R
FAU - Rodriguez, Marta
AU  - Rodriguez M
FAU - Ortin, Xavier
AU  - Ortin X
FAU - Masdeu, Gaspar
AU  - Masdeu G
FAU - Camps, Jordi
AU  - Camps J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120201
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
RN  - EC 3.1.8.1 (PON3 protein, human)
SB  - IM
MH  - Aged
MH  - Amino Acid Sequence
MH  - Aryldialkylphosphatase/*blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Intensive Care Units
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Oxidative Stress/physiology
MH  - Prospective Studies
MH  - Sepsis/*blood/enzymology/therapy
EDAT- 2012/08/08 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/12/02 00:00 [received]
PHST- 2012/01/01 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - /j/cclm.2012.50.issue-8/cclm-2011-0896/cclm-2011-0896.xml [pii]
AID - 10.1515/cclm-2011-0896 [doi]
PST - epublish
SO  - Clin Chem Lab Med. 2012 Feb 1;50(8):1409-15. doi: 10.1515/cclm-2011-0896.