PMID- 22869293
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20130521
IS  - 1424-8638 (Electronic)
IS  - 1424-862X (Linking)
VI  - 21
IP  - 3-4
DP  - 2013
TI  - Modulation of action potential trains in rabbit saphenous nerve unmyelinated 
      fibers.
PG  - 213-28
LID - 10.1159/000337350 [doi]
AB  - Usually, the main axon is assumed to faithfully conduct action potentials (APs). 
      Recent data have indicated that neural processing can occur along the axonal 
      path. However, the patterns and mechanisms of temporal coding are not clear. In 
      the present study, single fiber recording was used to analyze activity-dependent 
      modulation of AP trains in the main axons of C fibers in the rabbit saphenous 
      nerve. Trains of 5 superthreshold electrical pulses at interstimulus intervals of 
      20 or 50 ms were applied to the nerve trunk for 200 s. The interspike intervals 
      (ISIs) for these trains were compared to the input interstimulus intervals. Three 
      basic types of C fibers were observed in response to repeated stimuli: first, the 
      ISI between the first and second AP (ISI1-2) of type 1 was longer than the 
      interstimulus interval; second, the ISI1-2 of type 2 showed wavelike fluctuations 
      around the interstimulus interval, and third, the ISI1-2 of type 3 exhibited 
      shorter intervals for a long period. Furthermore, both 4-aminopyridine-sensitive 
      potassium and hyperpolarization-activated cation currents were involved in the 
      modulation of ISI1-2 of train pulses. These data provide new evidence that 
      multiple modes of neural conduction can occur along the main axons of C fibers.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Zhu, Zhi-Ru
AU  - Zhu ZR
AD  - Institute of Neuroscience, Fourth Military Medical University, Xi'an, Shaanxi 
      710032, PR China.
FAU - Liu, Yi-Hui
AU  - Liu YH
FAU - Ji, Wei-Gang
AU  - Ji WG
FAU - Duan, Jian-Hong
AU  - Duan JH
FAU - Hu, San-Jue
AU  - Hu SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120801
PL  - Switzerland
TA  - Neurosignals
JT  - Neuro-Signals
JID - 101134359
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Axons/physiology
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - Female
MH  - Femoral Nerve/*physiology
MH  - Male
MH  - Nerve Fibers, Unmyelinated/*physiology
MH  - Neural Conduction/physiology
MH  - Rabbits
EDAT- 2012/08/08 06:00
MHDA- 2013/12/24 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/08/22 00:00 [received]
PHST- 2012/02/20 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - 000337350 [pii]
AID - 10.1159/000337350 [doi]
PST - ppublish
SO  - Neurosignals. 2013;21(3-4):213-28. doi: 10.1159/000337350. Epub 2012 Aug 1.