PMID- 22870093
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 1
IP  - 6
DP  - 2010 Nov
TI  - Insertion of the 3' ABL region into the long arm of chromosome 1 in a 
      Philadelphia chromosome-negative chronic myeloid leukemia case.
PG  - 951-954
AB  - Chronic myeloid leukemia (CML) is a pluripotent hematopoietic stem cell disorder 
      almost always characterized by the presence of the Philadelphia chromosome (Ph), 
      usually due to t(9;22)(q34;q11). The presence of Ph results in the formation of 
      the BCR/ABL fusion gene, which is a constitutively activated tyrosine kinase. 
      Approximately 1% of CML patients appear to have a Ph-negative karyotype but carry 
      a cryptic BCR/ABL fusion that can be located by fluorescence in situ 
      hybridization (FISH) at chromosome 22q11, 9q34 or a third chromosome. This study 
      investigated a rare Ph-negative CML case with insertion of the 3' ABL region into 
      the long arm of derivative chromosome 1 but lacking the 5' BCR region on der(22).
FAU - Al-Achkar, Walid
AU  - Al-Achkar W
AD  - Molecular Biology and Biotechnology Department, Human Genetics Division, Atomic 
      Energy Commission of Syria, Damascus, Syria.
FAU - Liehr, Thomas
AU  - Liehr T
FAU - Wafa, Abdulsamad
AU  - Wafa A
LA  - eng
PT  - Journal Article
DEP - 20100923
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3412448
EDAT- 2010/11/01 00:00
MHDA- 2010/11/01 00:01
PMCR- 2010/09/23
CRDT- 2012/08/08 06:00
PHST- 2010/06/09 00:00 [received]
PHST- 2010/08/18 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2010/11/01 00:01 [medline]
PHST- 2010/09/23 00:00 [pmc-release]
AID - ol-01-06-0951 [pii]
AID - 10.3892/ol.2010.180 [doi]
PST - ppublish
SO  - Oncol Lett. 2010 Nov;1(6):951-954. doi: 10.3892/ol.2010.180. Epub 2010 Sep 23.