PMID- 22871233
OWN - NLM
STAT- MEDLINE
DCOM- 20140826
LR  - 20231213
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 60
IP  - 34
DP  - 2012 Aug 29
TI  - Isoflavones suppress the expression of the FcepsilonRI high-affinity immunoglobulin E 
      receptor independent of the estrogen receptor.
PG  - 8379-85
LID - 10.1021/jf301759s [doi]
AB  - Isoflavones found in soybeans and soy products possess clinically relevant 
      properties. However, the anti-allergic effect of isoflavones has been poorly 
      studied. We examined the effects of isoflavones, genistein, daidzein, and equol, 
      on the expression of the high-affinity immunoglobulin E (IgE) receptor, FcepsilonRI, 
      which plays a central role in IgE-mediated allergic response. Flow cytometric 
      analysis showed that all of these isoflavones reduced the cell surface expression 
      of FcepsilonRI on mouse bone-marrow-derived mast cells and human basophilic KU812 
      cells. All isoflavones decreased the levels of the FcepsilonRIalpha mRNA in the cells. 
      Genistein reduced the mRNA expression of the beta chain, and daidzein and equol 
      downregulated that of the gamma chain. The suppressive effects of isoflavones on 
      FcepsilonRI expression were unaffected by ICI 182,780, an estrogen receptor antagonist, 
      suggesting that these effects were independent of estrogen receptors.
FAU - Yamashita, Shuya
AU  - Yamashita S
AD  - Division of Applied Biological Chemistry, Department of Bioscience and 
      Biotechnology, Faculty of Agriculture, Kyushu University , Fukuoka 812-8581, 
      Japan.
FAU - Tsukamoto, Shuntaro
AU  - Tsukamoto S
FAU - Kumazoe, Motofumi
AU  - Kumazoe M
FAU - Kim, Yoon-hee
AU  - Kim YH
FAU - Yamada, Koji
AU  - Yamada K
FAU - Tachibana, Hirofumi
AU  - Tachibana H
LA  - eng
PT  - Journal Article
DEP - 20120816
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Estrogen Antagonists)
RN  - 0 (FcepsilonRI alpha-chain, human)
RN  - 0 (Isoflavones)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, IgE)
RN  - 22X328QOC4 (Fulvestrant)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4TI98Z838E (Estradiol)
RN  - 531-95-3 (Equol)
RN  - 6287WC5J2L (daidzein)
RN  - DH2M523P0H (Genistein)
RN  - EC 2.7.11.24 (MAPK1 protein, human)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/pharmacology
MH  - Basophils/drug effects/metabolism
MH  - Cell Line/drug effects
MH  - Equol/pharmacology
MH  - Estradiol/analogs & derivatives/pharmacology
MH  - Estrogen Antagonists/pharmacology
MH  - Fulvestrant
MH  - Genistein/pharmacology
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Isoflavones/*pharmacology
MH  - Male
MH  - Mast Cells/drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Phosphorylation/drug effects
MH  - Receptors, Estrogen/*metabolism
MH  - Receptors, IgE/genetics/*metabolism
MH  - Glycine max/chemistry
EDAT- 2012/08/09 06:00
MHDA- 2014/08/27 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2014/08/27 06:00 [medline]
AID - 10.1021/jf301759s [doi]
PST - ppublish
SO  - J Agric Food Chem. 2012 Aug 29;60(34):8379-85. doi: 10.1021/jf301759s. Epub 2012 
      Aug 16.