PMID- 22871614
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20240329
IS  - 0975-4466 (Electronic)
IS  - 0256-4947 (Print)
IS  - 0256-4947 (Linking)
VI  - 32
IP  - 5
DP  - 2012 Sep-Oct
TI  - Correlation between plasma N-terminal pro-brain natriuretic peptide levels and 
      changes in New York Heart Association functional class, left atrial size, left 
      ventricular size and function after mitral and/or aortic valve replacement.
PG  - 469-72
LID - 10.5144/0256-4947.2012.469 [doi]
AB  - BACKGROUND AND OBJECTIVES: Elevated plasma brain natriuretic peptide (BNP) levels 
      have been demonstrated in patients with chronic valvular disease. We designed the 
      present study to assess whether changes in N-terminal pro-brain natriuretic 
      peptide (NT-proBNP) levels after mitral, aortic and double mitral and aortic 
      valve replacement reflect changes in heart failure (HF) symptoms including New 
      York Heart Association (NYHA) class and changes in left atrium (LA) size, left 
      ventricle (LV) size and LV function. DESIGN AND SETTING: A prospective 
      observational nonrandomized study among consecutive patients undergoing mitral 
      and/or aortic valve replacement in our center. PATIENTS AND METHODS: The study 
      population consisted of 24 patients (mean [SD] age of 55.3 [16.2] years, 58% were 
      males) who underwent surgical mitral valve replacement (12 patients), aortic 
      valve replacement (8 patients) and combined mitral and aortic valve replacement 
      (4 patients). NT-proBNP measurements, transthoracic echocardiography and NYHA 
      class assessments were performed before and 6 months after surgery. RESULTS: The 
      decrease in NT-proBNP was associated with decrease in left atrial dimension (r = 
      0.73, P < .002), LV end-diastolic dimension (r=0.65, P=.001), LV end-systolic 
      dimension (r=0.53, P=.036), and increase in ejection fraction (r=-0.65, P=.001) 
      after 6 months postoperatively. Furthermore, a decreasing NT-proBNP was 
      associated with improvement in NYHA class. CONCLUSIONS: NT-proBNP levels after 
      mitral, aortic and double valve replacement correlates with changes in HF 
      manifestations as well as changes in LA size and LV dimension and function. Thus, 
      we hypothesize that interval measurement of the NT-proBNP level at clinic visits 
      can allow early detection of any clinical deterioration as well as the 
      possibility of assessment of the long-term outcome of those patients.
FAU - Elasfar, Abdelfatah
AU  - Elasfar A
AD  - Cardiology Department, Prince Salman Heart Center, King Fahad Medical City, 
      Riyadh, Saudi Arabia. elasfar_egy@hotmail.com
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Ann Saudi Med
JT  - Annals of Saudi medicine
JID - 8507355
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Aortic Valve/*surgery
MH  - Female
MH  - Heart Atria/*pathology
MH  - Heart Failure/blood/*pathology/*physiopathology
MH  - *Heart Valve Prosthesis Implantation
MH  - Heart Ventricles/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*surgery
MH  - Natriuretic Peptide, Brain/*blood
MH  - Organ Size
MH  - Peptide Fragments/*blood
MH  - Prospective Studies
MH  - *Ventricular Function, Left
PMC - PMC6080987
EDAT- 2012/08/09 06:00
MHDA- 2012/11/14 06:00
PMCR- 2012/09/01
CRDT- 2012/08/09 06:00
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - asm-5-469 [pii]
AID - 10.5144/0256-4947.2012.469 [doi]
PST - ppublish
SO  - Ann Saudi Med. 2012 Sep-Oct;32(5):469-72. doi: 10.5144/0256-4947.2012.469.