PMID- 22871675
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20130502
IS  - 1473-6543 (Electronic)
IS  - 1062-4821 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Sep
TI  - Novel role for the incretins in blood pressure regulation.
PG  - 463-8
LID - 10.1097/MNH.0b013e328356bccd [doi]
AB  - PURPOSE OF REVIEW: Incretin-based therapies are currently being used in the 
      treatment of type 2 diabetes mellitus (T2DM). Apart from glycemic control, these 
      agents have been shown to have multiple extra-pancreatic effects, including their 
      role in blood pressure (BP) regulation. This article will review the origins of 
      incretins, the incretin axis, possible mechanisms of antihypertensive effect of 
      these agents, as well as the recent evidence. RECENT FINDINGS: Preclinical and 
      clinical studies demonstrate the antihypertensive effects of glucagon-like 
      peptide-1 (GLP-1) and its analogs in patients with T2DM and hypertension. This 
      effect seems to be mediated through vasodilatation as well as modulation of renal 
      sodium handling causing natriuresis, although the exact mechanisms are not fully 
      known. SUMMARY: Incretin-based therapies are emerging as a novel class of 
      hypoglycemic agents that display antihypertensive properties. Given the small 
      decreases in BP, it is unlikely that these agents will be used as stand-alone 
      antihypertensive agents, but they may be an attractive option in patients with 
      T2DM and hypertension.
FAU - Yerram, Preethi
AU  - Yerram P
AD  - Division of Nephrology and Hypertension, Department of Internal Medicine, 
      University of Missouri-Columbia School of Medicine, Columbia, Missouri 65212, 
      USA. yerramp@health.misouri.edu
FAU - Whaley-Connell, Adam
AU  - Whaley-Connell A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Nephrol Hypertens
JT  - Current opinion in nephrology and hypertension
JID - 9303753
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Incretins)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Antihypertensive Agents/*therapeutic use
MH  - Blood Pressure/*drug effects/physiology
MH  - Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Glucagon-Like Peptide 1/metabolism
MH  - Humans
MH  - Hypertension/complications/*drug therapy
MH  - Incretins/*therapeutic use
EDAT- 2012/08/09 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.1097/MNH.0b013e328356bccd [doi]
PST - ppublish
SO  - Curr Opin Nephrol Hypertens. 2012 Sep;21(5):463-8. doi: 
      10.1097/MNH.0b013e328356bccd.