PMID- 22873349
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20211021
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 11
DP  - 2012 Aug 8
TI  - Effect of telmisartan on the expression of adiponectin receptors and nicotinamide 
      adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic 
      rats.
PG  - 94
LID - 10.1186/1475-2840-11-94 [doi]
AB  - BACKGROUND: Diabetic cardiovascular disease is associated with decreased 
      adiponectin and increased oxidative stress. This study investigated the effect of 
      telmisartan on the expression of adiponectin receptor 2 (adipoR2) and 
      nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in the heart 
      and the expression of adiponectin receptor 1 (adipoR1) in aorta in type 2 
      diabetic rats. METHODS: Type 2 diabetes was induced by high-fat and high-sugar 
      diet and intraperitoneal injection of a low dose of streptozotocin (STZ). Heart 
      function, adipoR2, p22phox, NOX4, glucose transporter 4(GLUT4), monocyte 
      chemoattractant protein-1(MCP-1) and connective tissue growth factor (CTGF)in the 
      heart, and adipoR1, MCP-1 and nuclear factor kappa B (NF-kappaB) in aorta were 
      analyzed in controls and diabetic rats treated with or without telmisartan 
      (5mg/kg/d) by gavage for 12 weeks. RESULTS: Heart function, plasma and myocardial 
      adiponectin levels, the expression of myocardial adipoR2 and GLUT4 were 
      significantly decreased in diabetic rats (P <0.05). The expression of myocardial 
      p22phox, NOX4, MCP-1, and CTGF was significantly increased in diabetic rats (P 
      <0.05). The expression of adipoR1 was decreased and the expression of MCP-1 and 
      NF-kappaB was increased in the abdominal aorta in diabetic rats (P <0.05). 
      Telmisartan treatment significantly attenuated these changes in diabetic rats (P 
      <0.05). CONCLUSIONS: Our results suggest that telmisartan upregulates the 
      expression of myocardial adiponectin, its receptor 2 and GLUT4. Simultaneously, 
      it downregulates the expression of myocardial p22phox, NOX4, MCP-1, and CTGF, 
      contributing so to the improvement of heart function in diabetic rats. 
      Telmisartan also induces a protective role on the vascular system by upregulating 
      the expression of adipoR1 and downregulating the expression of MCP-1 and NF-kappaB in 
      the abdominal aorta in diabetic rats.
FAU - Guo, Zhixin
AU  - Guo Z
AD  - Department of Endocrinology, Second Hospital, Shanxi Medical University, 382 Wuyi 
      Road, Taiyuan, Shanxi, P.R. China. zhxguo1966@yahoo.com.cn
FAU - Zhang, Rong
AU  - Zhang R
FAU - Li, Jiawei
AU  - Li J
FAU - Xu, Guojun
AU  - Xu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120808
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Adiponectin)
RN  - 0 (Adipoq protein, rat)
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Benzimidazoles)
RN  - 0 (Benzoates)
RN  - 0 (CCN2 protein, mouse)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Adiponectin)
RN  - 0 (Slc2a4 protein, rat)
RN  - 0 (adiponectin receptor 1, rat)
RN  - 0 (adiponectin receptor 2, rat)
RN  - 139568-91-5 (Connective Tissue Growth Factor)
RN  - EC 1.6.3.- (NADPH Oxidase 4)
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - EC 1.6.3.- (Nox4 protein, rat)
RN  - EC 1.6.3.1 (Cyba protein, rat)
RN  - U5SYW473RQ (Telmisartan)
SB  - IM
MH  - Adiponectin/metabolism
MH  - Angiotensin II Type 1 Receptor Blockers/*pharmacology
MH  - Animals
MH  - Aorta, Abdominal/*drug effects/metabolism/pathology
MH  - Benzimidazoles/*pharmacology
MH  - Benzoates/*pharmacology
MH  - Chemokine CCL2/metabolism
MH  - Connective Tissue Growth Factor/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy/enzymology/genetics/pathology
MH  - Diabetes Mellitus, Type 2/*drug therapy/enzymology/genetics/pathology
MH  - Gene Expression Regulation
MH  - Glucose Transporter Type 4/metabolism
MH  - Male
MH  - Myocardium/*enzymology/pathology
MH  - NADPH Oxidase 4
MH  - NADPH Oxidases/genetics/*metabolism
MH  - NF-kappa B/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adiponectin/*drug effects/genetics/*metabolism
MH  - Telmisartan
PMC - PMC3471013
EDAT- 2012/08/10 06:00
MHDA- 2013/03/21 06:00
PMCR- 2012/08/08
CRDT- 2012/08/10 06:00
PHST- 2012/07/19 00:00 [received]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PHST- 2012/08/08 00:00 [pmc-release]
AID - 1475-2840-11-94 [pii]
AID - 10.1186/1475-2840-11-94 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2012 Aug 8;11:94. doi: 10.1186/1475-2840-11-94.